Y-33075 dihydrochloride

规格	价格/CNY		数量
1 mg	￥ 259	现货
2 mg	￥ 369	现货
5 mg	￥ 591	现货
10 mg	￥ 978	现货
25 mg	￥ 2,380	现货
50 mg	￥ 3,820	现货
100 mg	￥ 5,530	现货
500 mg	￥ 11,500	现货
1 mL * 10 mM (in DMSO)	￥ 830	现货

规格

价格/CNY

货期

数量

1 mg

￥ 259

现货

2 mg

￥ 369

现货

5 mg

￥ 591

现货

10 mg

￥ 978

现货

25 mg

￥ 2,380

现货

50 mg

￥ 3,820

现货

100 mg

￥ 5,530

现货

500 mg

￥ 11,500

现货

1 mL * 10 mM (in DMSO)

￥ 830

现货

存储

store at low temperature,keep away from direct sunlight　|　Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 100 mg/mL (283.09 mM), Sonification is recommended.

H2O: 50 mg/mL (141.54 mM), Sonification is recommended.

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO / H2O	1 mM	2.8309 mL	14.1543 mL	28.3086 mL	70.7714 mL
	5 mM	0.5662 mL	2.8309 mL	5.6617 mL	14.1543 mL
	10 mM	0.2831 mL	1.4154 mL	2.8309 mL	7.0771 mL
	20 mM	0.1415 mL	0.7077 mL	1.4154 mL	3.5386 mL
	50 mM	0.0566 mL	0.2831 mL	0.5662 mL	1.4154 mL
	100 mM	0.0283 mL	0.1415 mL	0.2831 mL	0.7077 mL

产品描述	Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).
靶点活性	PKC:420 nM, ROCK:3.6 nM, CaMK II:810 nM
体外活性	Y-33075 (Y-39983) is a potent inhibitor of ROCK(IC50 of 3.6 nM). Y-33075 also inhibits PKC and CaMKII more potently than Y-27632(IC50s of Y-27632 and Y-33075 for PKC are 9.0 μM and 0.42 μM, respectively), whereas the IC50s of Y-27632 and Y-33075 for CaMKII are 26 μM and 0.81 μM, respectively. The IC50s of Y-27632 and Y-33075 for PKC is 82 and 117 times those for ROCK, respectively, whereas the IC50s of Y-27632 and Y-33075 for CaMKII is 236 and 225 times those for ROCK, respectively[1]. Y-33075 (Y-39983, 10 μM) extends neurites in the retinal ganglion cells (RGCs) compared with those in RGCs treated without Y-39983[2]. Y-33075 (Y-39983, 1 μM) inhibits the contraction of rabbit ciliary artery segments evoked by histamine in Ca2+-free solutions[3].
体内活性	Y-39983 (≥0.01%) significantly lowers intraocular pressure (IOP) at 2 hours after topical administration in rabbits. Y-39983 (0.05%)-treated eyes show significant reduction of IOP between 2 and 7 hours after topical administration in monkeys[1]. Y-39983 (100 μM) increases the regenerating axons of retinal ganglion cells (RGCs) in the eyes of the rats[2].

分子量	353.25
分子式	C16H18Cl2N4O
CAS No.	173897-44-4

存储

溶解度

溶液配制表

计算器

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