Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Valbenazine (NBI-98854) 是一种高度选择性的囊泡单胺转运蛋白 2 (VMAT2) 抑制剂,Ki 为 110-190 nM,用于治疗迟发性运动障碍。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 343 | 现货 | ||
2 mg | ¥ 496 | 现货 | ||
5 mg | ¥ 993 | 现货 | ||
10 mg | ¥ 1,590 | 现货 | ||
25 mg | ¥ 2,930 | 现货 | ||
50 mg | ¥ 4,430 | 现货 | ||
100 mg | ¥ 6,260 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 996 | 现货 |
产品描述 | Valbenazine (NBI-98854), a highly selective vesicular monoamine transporter 2(VMAT2) inhibitor, is approved for the treatment of tardive dyskinesia. |
体内活性 | Valbenazine appeared to be well tolerated in adults with TD who received up to 48 weeks of treatment. In addition to long-term efficacy results, Suggest that valbenazine may be appropriate for the long-term management of TD regardless of underlying psychiatric diagnosis (SCHZ disorder or mood disorder)[1]. |
动物实验 | The pooled long-term exposure (LTE) population included valbenazine-treated subjects from 3 studies: KINECT; KINECT 3; KINECT4. Safety assessments included adverse events (AEs), laboratory tests, vital signs, electrocardiograms (ECGs), and extrapyramidal symptom (EPS) scales. Psychiatric stability was monitored using the Positive and Negative Syndrome Scale (PANSS) and Calgary Depression Scale for Schizophrenia (CDSS) (SCHZ subgroup), as well as the Montgomery-?sberg Depression Rating Scale (MADRS) and Young Mania Rating Scale (YMRS) (mood subgroup). All data were analyzed descriptively[1]. |
别名 | NBI-98854 |
分子量 | 418.57 |
分子式 | C24H38N2O4 |
CAS No. | 1025504-45-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (119.45 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3891 mL | 11.9454 mL | 23.8909 mL | 59.7272 mL |
5 mM | 0.4778 mL | 2.3891 mL | 4.7782 mL | 11.9454 mL | |
10 mM | 0.2389 mL | 1.1945 mL | 2.3891 mL | 5.9727 mL | |
20 mM | 0.1195 mL | 0.5973 mL | 1.1945 mL | 2.9864 mL | |
50 mM | 0.0478 mL | 0.2389 mL | 0.4778 mL | 1.1945 mL | |
100 mM | 0.0239 mL | 0.1195 mL | 0.2389 mL | 0.5973 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Valbenazine 1025504-45-3 Membrane transporter/Ion channel Monoamine Transporter disease VMAT2 NBI 98854 monoamine transporter inhibit Huntington Inhibitor vesicular NBI-98854 NBI98854 inhibitor