购物车

您的购物车当前为空

Tricyclazole

Name: Tricyclazole
Brand: TargetMol
SKU: T5955
Price: 145 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 95.79%

货号 T5955Cas号 41814-78-2

别名 三环唑, Tricyclazol

Tricyclazole (Tricyclazol) 是一种源自五肽的黑色素生物合成抑制剂，是一种独特的杀菌剂，用于防治水稻稻瘟病菌。

为众多的药物研发团队赋能，

让新药发现更简单！

Tricyclazole

一键复制产品信息

很棒

纯度: 95.79%

货号 T5955 别名 三环唑, TricyclazolCas号 41814-78-2

Tricyclazole (Tricyclazol) 是一种源自五肽的黑色素生物合成抑制剂，是一种独特的杀菌剂，用于防治水稻稻瘟病菌。

规格	价格	库存
10 mg	¥ 145	现货
25 mg	¥ 212	现货
50 mg	¥ 293	现货
100 mg	¥ 415	现货
500 mg	¥ 986	现货
1 g	¥ 1,450	现货
1 mL x 10 mM (in DMSO)	¥ 466	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 95.79%

联系我们获取更多批次信息

资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Tricyclazole AI Summary

Tricyclazole exhibits multifaceted bioactivity, acting as an inhibitor, agonist, and antifungal agent. It inhibits Trihydroxynaphthalene reductase with a potent inhibition constant (Ki) of 24.0 nM. Additionally, it functions as a small molecule agonist for the antioxidant response element (ARE) signaling pathway with an agonistic potency of 2730.6 nM, and similarly activates the human pregnane X receptor (PXR) signaling pathway with a potency of 63095.7 nM, as well as displaying Nrf2-dependent transcriptional activity with a potency of 48557.7 nM. In the realm of antifungal activity, Tricyclazole shows significant efficacy against Magnaporthe grisea and Magnaporthe oryzae, responsible for rice blast disease. It demonstrates complete control over the disease in pre-treated rice seedlings at 10 ug/mL and maintains high efficacy at concentrations as low as 0.5 ug/mL. It offers dose-dependent inhibition, with an IC50 value of 474000.0 nM, achieving up to 94.0% growth inhibition at 200 ug/mL. The compound effectively prevents mycelium growth and conidia germination, indicating potential as a fungicide with an ED90 of 215.64 mg/L and an EC50 of 0.072 ug/mL for sporulation inhibition. Further illustrating its fungicidal properties, Tricyclazole exhibits activity against other fungal strains like Rhizoctonia solani, Phytophthora capsici, Botryotinia fuckeliana, and Sclerotinia sclerotiorum, demonstrating varying inhibition rates at different concentrations. Specifically, it shows high inhibition percentages against Penicillium crustosum and moderate activity against Magnaporthe grisea in multiple experimental setups. Moreover, Tricyclazole has demonstrated binding affinity towards recombinant GST-tagged human BRPF1 with a dissociation constant (Kd) of 21,000.0 nM, indicating its potential interactions within human protein targets. These multifaceted biological effects suggest Tricyclazole as a promising candidate for further pharmacological and agrochemical research and development..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Tricyclazole (Tricyclazol) is a pentaketide-derived melanin biosynthesis inhibitor. Tricyclazole is a a unique fungicide for control of Pyricularia oryzae on rice.
别名	三环唑, Tricyclazol

化学信息

分子量	189.24
分子式	C₉H₇N₃S
CAS No.	41814-78-2
Smiles	Cc1cccc2sc3nncn3c12
密度	1.2292 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 16.67 mg/mL (88.09 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.57 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2843 mL	26.4215 mL	52.8430 mL	264.2148 mL
5 mM	1.0569 mL	5.2843 mL	10.5686 mL	52.8430 mL
10 mM	0.5284 mL	2.6421 mL	5.2843 mL	26.4215 mL
20 mM	0.2642 mL	1.3211 mL	2.6421 mL	13.2107 mL
50 mM	0.1057 mL	0.5284 mL	1.0569 mL	5.2843 mL