Powder: -20°C for 3 years
In solvent: -80°C for 2 years
LNP023 hydrochloride 是一种可口服、高效和高选择性的因子 B 抑制剂，IC50 为 10 nM。 LNP023 显示与人因子 B 的直接、可逆和高亲和力结合，KD 为 7.9 nM。
| 产品描述 | LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. LNP023 shows direct, reversible, and high-affinity binding to human factor B with a KD of 7.9 nM. |
| 靶点活性 | factor B:10 nM, factor B:7.9 nM(KD) |
| 体外活性 | LNP023 demonstrates excellent selectivity over other proteases affording IC50 values of >30 μM across a panel of 41 human proteases, including the AP protein factor D (>100 μM)[3]. |
| 体内活性 | LNP023 (20-180 mg/kg; oral administration) is effective upon prophylactic and therapeutic dosing in an experimental model of membranous nephropathy in rats and prevents KRN (150 μL)-induced arthritis in mice[2]. After oral administration (rat 30 and, dog 10 mg/kg), LNP023 exhibits moderate half-lives (T1/2; Wistar Han rats 3.4 h, beagle dogs 5.5 h) and Cmax (Wistar Han rats 410 nM, beagle dogs 2200 nM)[3]. |
| 别名 | LNP023 hydrochloride, Iptacopan HCl |
| 分子量 | 458.98 |
| 分子式 | C25H31ClN2O4 |
| CAS No. | 1646321-63-2 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
H2O: 50 mg/mL (108.94 mM), ultrasonic and warming
DMSO: 250 mg/mL (544.69 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
参考文献
剂量换算对于不同动物的给药剂量换算，您也可以参考 更多
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您可能有的问题的答案可以在抑制剂处理说明中找到，包括如何准备库存溶液，如何存储产品，以及基于细胞的分析和动物实验需要特别注意的问题。
Iptacopan hydrochloride 1646321-63-2 Immunology/Inflammation Complement System LNP 023 hemoglobinuria inhibit PNH atypical pathogenesis LNP023 hydrochloride Inhibitor LNP023 factor B system Iptacopan complement Iptacopan HCl paroxysmal syndrome LNP-023 pathway hemolytic uremic alternative nocturnal inhibitor
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