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Search Results for " nocturnal "

Targets Recommended: Complement System

10

抑制剂 & 化合物

1

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9189	Iptacopan hydrochloride Iptacopan HCl,LNP023 hydrochloride	Complement System	Immunology/Inflammation
	Iptacopan hydrochloride (LNP023 hydrochloride) 是一种可口服、高效和高选择性的因子 B 抑制剂，IC50 为 10 nM。 LNP023 显示与人因子 B 的直接、可逆和高亲和力结合，KD 为 7.9 nM。
T1627	Famotidine MK-208,法莫替丁	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Famotidine (MK-208) 是一种具有抗酸活性的丙脒和组胺 H2 受体拮抗剂。
T5019	Desmopressin 去氨加压素,DDAVP,Desmopressin Acetate	Vasopressin Receptor	GPCR/G Protein
	Desmopressin (DDAVP) 是抗利尿激素精氨酸加压素的合成类似物。
T5144	Desmopressin acetate (16679-58-6 free base) Desmopressin acetate,醋酸去氨加压素,DDAVP	Vasopressin Receptor	GPCR/G Protein
	Desmopressin acetate (16679-58-6 free base) (DDAVP) 是抗利尿激素精氨酸加压素的合成类似物。
T8509	Danicopan ACH-4471	Complement System	Immunology/Inflammation
	Danicopan (ACH-4471) 是一种可口服的小分子 D 因子选择性抑制剂，对人 D 因子具有高结合亲和力，Kd 值为 0.54 nM。它可抑制补体替代途径 (APC) 的活性，具有阻断阵发性夜间血红蛋白尿 (PNH) 和非典型溶血性尿毒症综合征 (aHUS) 的补体替代途径的潜力。
T68799	Lupitidine hydrochloride
	Lupitidine hydrochloride inhibits nocturnal acid secretion.
T26577	AGN-201904Z AGN-201904-Z,AGN-201904
	AGN-201904Z is a slowly absorbed, acid-stable pro-proton pump inhibitor (pro-PPI) rapidly converted to omeprazole in the systemic circulation giving a prolonged residence time. AGN 201904-Z produced a significantly greater, and nocturnal acid suppression
T70070	Cisapride tartrate
	Cisapride tartrate is chemically related to metoclopramide, but unlike metoclopramide, it does not cross the blood-brain barrier or have antidopaminergic effects. Cisapride is a serotonin-4 (5-HT4) receptor agonist. Cisapride was indicated for the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease. The Food and Drug Administration (FDA) in America stopped the marketing of cisapride as of 14th July 2000. They had received at least 341 reports o...
T77190	Crovalimab
	Crovalimab (SKY59; RO7112689)是一种人源化抗C5抗体，其通过pH依赖性机制发挥作用，其KD值在pH 7.4时为15.2nM，在pH 5.8时为16.8μM。该化合物还以高亲和力结合于人FcRn(KD: 17μM; pH 6.0)。通过阻断C5转化酶对C5的切割及抑制C5变体(p.Arg885His)的活性，Crovalimab能够显著抑制补体系统中经典途径(CP)、凝集素途径(LP)以及旁路途径(AP)中C5b-9的形成。因此，Crovalimab展现出作为研究阵发性睡眠性血红蛋白尿(PNH)及其他补体介导疾病的潜力。
T64692	AMY-101 acetate
	Complement component C3 plays a particularly versatile role in this process by keeping the cascade alert, acting as a point of convergence of activation pathways, fueling the amplification of the complement response, exerting direct effector functions, and helping to coordinate downstream immune responses[3]. In C3-/- mice alcohol-induced liver steatosis is absent or strongly reduced after chronic or acute alcohol exposure. This suggests that the complement system and its component C3 contribute...

化合物

Iptacopan hydrochloride

Cat.No: T9189

Synonym: Iptacopan HCl,LNP023 hydrochloride

Target: Complement System

Cat.No: T1627

Synonym: MK-208,法莫替丁

Target: Histamine Receptor

Cat.No: T5019

Synonym: 去氨加压素,DDAVP,Desmopressin Acetate

Target: Vasopressin Receptor

Desmopressin acetate (16679-58-6 free base)

Cat.No: T5144

Synonym: Desmopressin acetate,醋酸去氨加压素,DDAVP

Target: Vasopressin Receptor

Cat.No: T8509

Synonym: ACH-4471

Target: Complement System

Lupitidine hydrochloride

Cat.No: T68799

Cat.No: T26577

Synonym: AGN-201904-Z,AGN-201904

Cisapride tartrate

Cat.No: T70070

Cat.No: T77190

AMY-101 acetate

Cat.No: T64692

Cat. No.	Product Name	Target	Signaling Pathways
T20326	1,2-Dimethoxybenzene Veratrole,AI302281,AI3 02281,AI3-02281	Others	Others
	1,2-Dimethoxybenzene (Veratrole) 是由Silene latifolia 分泌天然产物，是对夜行性蛾Hadena bicruris 有效传粉的引诱剂。

天然产物

1,2-Dimethoxybenzene

Cat.No: T20326

Synonym: Veratrole,AI302281,AI3 02281,AI3-02281

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02266	CD59a Protein, Mouse, Recombinant (His) CD59a antigen,Cd59,protectin,RP24-297H17.1,AA987121	Mouse	HEK293
	Protectin, a complement regulatory protein, also known as CD59, or MIRL (membrane inhibitor of reactive lysis) is a small protein that inhibits the complement membrane attack complex by binding C5b678 and preventing C9 from binding and polymerizing. The amino-terminal 25 amino acids represented a typical signal peptide sequence and the carboxy-terminal hydrophobic amino acids were characteristic for phosphatidylinositol-anchored proteins. It was found that the CD59/Protectin antigen is a small p...
TMPY-02503	CD59a Protein, Mouse, Recombinant (hFc) AA987121,CD59a antigen,Cd59,protectin,RP24-297H17.1	Mouse	HEK293
	Protectin, a complement regulatory protein, also known as CD59, or MIRL (membrane inhibitor of reactive lysis) is a small protein that inhibits the complement membrane attack complex by binding C5b678 and preventing C9 from binding and polymerizing. The amino-terminal 25 amino acids represented a typical signal peptide sequence and the carboxy-terminal hydrophobic amino acids were characteristic for phosphatidylinositol-anchored proteins. It was found that the CD59/Protectin antigen is a small p...

重组蛋白

CD59a Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02266

Species: Mouse

Expression System: HEK293

CD59a Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02503

Species: Mouse

Expression System: HEK293

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