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Cat. No. | Product Name | Target | Signaling Pathways |
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T9189 |
Iptacopan hydrochloride
Iptacopan HCl,LNP023 hydrochloride |
Complement System | Immunology/Inflammation |
Iptacopan hydrochloride (LNP023 hydrochloride) 是一种可口服、高效和高选择性的因子 B 抑制剂,IC50 为 10 nM。 LNP023 显示与人因子 B 的直接、可逆和高亲和力结合,KD 为 7.9 nM。 | |||
T76867 |
Ravulizumab
ALXN1210 |
Complement System | Immunology/Inflammation |
Ravulizumab (ALXN1210) 是一种靶向补体因子 5 的人源化单克隆抗体,它以高亲和力特异性结合人补体蛋白 C5,可阻断补体激活。Ravulizumab 可用于预防和治疗阵发性睡眠性血红蛋白尿症、非典型溶血性尿毒症综合征和重症肌无力。 | |||
T15257 |
Etripamil
MSP-2017,(-)-MSP-2017 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Etripamil (MSP-2017) 是一种短效L 型钙通道拮抗剂,可用于治疗阵发性室上性心动过速的研究。它通过抑制房室结细胞中钙慢通道的钙离子流入,显示房室结传导并延长房室结不应期 | |||
T8509 |
Danicopan
ACH-4471 |
Complement System | Immunology/Inflammation |
Danicopan (ACH-4471) 是一种可口服的小分子 D 因子选择性抑制剂,对人 D 因子具有高结合亲和力,Kd 值为 0.54 nM。 它可抑制补体替代途径 (APC) 的活性,具有阻断阵发性夜间血红蛋白尿 (PNH) 和非典型溶血性尿毒症综合征 (aHUS) 的补体替代途径的潜力。 | |||
T21391 |
Flecainide
Tambocor,Apocard,Flecainida,Flecainidum |
||
Flecainide acetate is a class Ic antiarrhythmic agent, it is used to treat a variety of cardiac arrhythmias including paroxysmal atrial fibrillation, paroxysmal supraventricular tachycardia, and ventricular tachycardia. It works by regulating the flow of | |||
T77190 | Crovalimab | ||
Crovalimab (SKY59; RO7112689)是一种人源化抗C5抗体,其通过pH依赖性机制发挥作用,其KD值在pH 7.4时为15.2nM,在pH 5.8时为16.8μM。该化合物还以高亲和力结合于人FcRn(KD: 17μM; pH 6.0)。通过阻断C5转化酶对C5的切割及抑制C5变体(p.Arg885His)的活性,Crovalimab能够显著抑制补体系统中经典途径(CP)、凝集素途径(LP)以及旁路途径(AP)中C5b-9的形成。因此,Crovalimab展现出作为研究阵发性睡眠性血红蛋白尿(PNH)及其他补体介导疾病的潜力。 | |||
T64692 |
AMY-101 acetate
|
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Complement component C3 plays a particularly versatile role in this process by keeping the cascade alert, acting as a point of convergence of activation pathways, fueling the amplification of the complement response, exerting direct effector functions, and helping to coordinate downstream immune responses[3]. In C3-/- mice alcohol-induced liver steatosis is absent or strongly reduced after chronic or acute alcohol exposure. This suggests that the complement system and its component C3 contribute... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02266 |
CD59a Protein, Mouse, Recombinant (His)
CD59a antigen,Cd59,protectin,RP24-297H17.1,AA987121 |
Mouse | HEK293 |
Protectin, a complement regulatory protein, also known as CD59, or MIRL (membrane inhibitor of reactive lysis) is a small protein that inhibits the complement membrane attack complex by binding C5b678 and preventing C9 from binding and polymerizing. The amino-terminal 25 amino acids represented a typical signal peptide sequence and the carboxy-terminal hydrophobic amino acids were characteristic for phosphatidylinositol-anchored proteins. It was found that the CD59/Protectin antigen is a small p... | |||
TMPY-01854 |
DPP10 Protein, Human, Recombinant (His)
DPPY,DPRP3,DPRP-3,DPL2,dipeptidyl-peptidase 10 (non-function... |
Human | HEK293 |
Inactive dipeptidyl peptidase 1, also known as Dipeptidyl peptidase IV-related protein 3, Dipeptidyl peptidase X, Dipeptidyl peptidase-like protein 2, DPRP-3, DPL2 and DPP1, is a single-pass type II membrane protein which belongs to thepeptidase S9B family.DPPIV subfamily. It may modulate cell surface expression and activity of the potassium channels KCND1 and KCND2. DPP1 / DPRP3 has no detectable protease activity, most likely due to the absence of the conserved serine residue normally p... | |||
TMPY-02503 |
CD59a Protein, Mouse, Recombinant (hFc)
AA987121,CD59a antigen,Cd59,protectin,RP24-297H17.1 |
Mouse | HEK293 |
Protectin, a complement regulatory protein, also known as CD59, or MIRL (membrane inhibitor of reactive lysis) is a small protein that inhibits the complement membrane attack complex by binding C5b678 and preventing C9 from binding and polymerizing. The amino-terminal 25 amino acids represented a typical signal peptide sequence and the carboxy-terminal hydrophobic amino acids were characteristic for phosphatidylinositol-anchored proteins. It was found that the CD59/Protectin antigen is a small p... |