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BACE

BACE

Beta-secretase 1 (BACE1), also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1, membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the BACE1 gene. Expression of BACE1 is observed mainly in neurons.BACE1 is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells: in mice the expression of BACE1 is high in the postnatal stages, when myelination occurs.
TargetMol
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Cat. No. Product Name CAS No. Purity Chemical Structure
TN2217 Sophoflavescenol
槐苦参醇
216450-65-6 99.65%
TargetMol Chemical Structure Sophoflavescenol
Sophoflavescenol 是异戊烯基黄酮类化合物,能够抑制PDE5的活性,IC50=0.013 μM。它也抑制 RLAR,HRAR,BACE1,AChE 和 BChE,IC50值分别为 0.30 µM,0.17 µM,10.98 µM,8.37 µM 和 8.21 µM。
TN3410 Anatabine
化合物 TN3410
581-49-7 98%
TargetMol Chemical Structure Anatabine
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN4865 Putraflavone
化合物 TN4865
23624-21-7 98%
TargetMol Chemical Structure Putraflavone
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
TN2131 Questin
化合物Questin
3774-64-9 98%
TargetMol Chemical Structure Questin
Questin 是一种从花样黄曲霉中提取出来的抗菌剂,具有抗菌活型,对V. harveyi,V. anguillarum,V. cholerae 和 V. parahemolyticus 具有抑制作用,MIC 值分别为 31.25 µg/mL,62.5 µg/mL,62.5 µg/mL 和 125 µg/mL。Quest...
TN1332 7-O-Methylaloeresin A
7-O-甲基片木素A
329361-25-3 98%
TargetMol Chemical Structure 7-O-Methylaloeresin A
7-O-Methylaloeresin A shows significant antioxidant activity, it also has moderate inhibitory active on BACE.
T10292 AM-6494
化合物 T10292
1874232-80-0 98%
TargetMol Chemical Structure AM-6494
AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).
T10450 BACE1-IN-1
化合物 T10450
1310347-50-2 98%
TargetMol Chemical Structure BACE1-IN-1
BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
TN1434 Bavachromene
补骨脂色烯查耳酮
41743-38-8 98%
TargetMol Chemical Structure Bavachromene
Bavachromene exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.
T8306 Epiberberine chloride
表小檗碱氯化物
889665-86-5 98%
TargetMol Chemical Structure Epiberberine chloride
Epiberberine chloride (Epiberberine (chloride)) 是一种从黄连中得到的生物碱,是一种AChE 和BChE 抑制剂,和非竞争性的BACE1抑制剂。它具有抗氧化作用,能够清除 ONOO-,可用于研究阿尔滋海默症和糖尿病。
T10452 BACE1-IN-4
化合物 T10452
2361157-92-6 98%
TargetMol Chemical Structure BACE1-IN-4
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.
T12429 PF-06751979
化合物 T12429
1818339-66-0 98%
TargetMol Chemical Structure PF-06751979
PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
TN4399 Kushenol C
化合物 TN4399
99119-73-0 98%
TargetMol Chemical Structure Kushenol C
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
T10453 BACE1-IN-5
化合物 T10453
2581114-83-0 98%
TargetMol Chemical Structure BACE1-IN-5
BACE1-IN-5 (Compound 15) 是一种 BACE1抑制剂,IC50为 9.1 nM。BACE1-IN-5还可抑制细胞 Aβ,IC50为 0.82 nM。并且,BACE1-IN-5 具有改善 hERG 抑制和 P-gp 外排的药物化学作用。
T10451 BACE1-IN-2
化合物 T10451
1352416-78-4 98%
TargetMol Chemical Structure BACE1-IN-2
BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).
T6058 LY2886721
化合物LY2886721
1262036-50-9 99.94%
TargetMol Chemical Structure LY2886721
LY2886721 是选择性的,口服活性的 β 位淀粉样蛋白前体蛋白裂解酶 1 抑制剂,对重组人 BACE1的 IC50=20.3 nM。它对 BACE1的选择性高于对组织蛋白酶 D、胃蛋白酶、肾素的选择性,但缺乏对 BACE2的选择性。它可透过血脑屏障,并可用于研究阿尔茨海默氏病。
T6772 AZD3839 free base
化合物AZD3839
1227163-84-9 99.93%
TargetMol Chemical Structure AZD3839 free base
AZD3839 free base 是一种具有口服活性的、选择性的、可透过大脑屏障的BACE1抑制剂 (Ki=26 nM),对 BACE2 和组织蛋白酶 D 的选择性分别为 14 倍和 >1000 倍。在小鼠、豚鼠和非人灵长类动物中,它剂量和时间依赖性的降低血浆、脑和脑脊液 Aβ 水平,可用于研究阿尔茨海默病。
T4398 LX2343
化合物LX2343
333745-53-2 99.92%
TargetMol Chemical Structure LX2343
LX2343 是一种非 ATP 竞争性 PI3K 抑制剂,IC50 为 15.99±3.23 μM。它是一种 BACE1 酶抑制剂,IC50 值为 11.43±0.36 μM。它在促进 Aβ 清除中刺激自噬。
T83616 SEW06622
化合物 SEW06622
261349-28-4 99.87%
TargetMol Chemical Structure SEW06622
SEW06622 是一种有效的 乙酰胆碱酯酶(AChE)和β-分泌酶-1(BACE-1)抑制剂,是治疗阿尔茨海默病的潜在候选化合物。
TN1343 8-Geranyloxypsoralen
8-香叶草氧基补骨脂素
7437-55-0 99.87%
TargetMol Chemical Structure 8-Geranyloxypsoralen
8-Geranyloxypsoralen 是一种呋喃香豆素,分离自葡萄柚,是 P450 3A4 的有效抑制剂(IC50:3.93 μM)。
T8179 Aloeresin D
芦荟新苷 D
105317-67-7 99.84%
TargetMol Chemical Structure Aloeresin D
Aloeresin D 是一种从芦荟中分离得到的色原酮苷,能够抑制 β-分泌酶活性,IC50=39 μM。
Sophoflavescenol
TN2217
Sophoflavescenol 是异戊烯基黄酮类化合物,能够抑制PDE5的活性,IC50=0.013 μM。它也抑制 RLAR,HRAR,BACE1,AChE 和 BChE,IC50值分别为 0.30 µM,0.17 µM,10.98 µM,8.37 µM 和 8.21 µM。
Anatabine
TN3410
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
Putraflavone
TN4865
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
Questin
TN2131
Questin 是一种从花样黄曲霉中提取出来的抗菌剂,具有抗菌活型,对V. harveyi,V. anguillarum,V. cholerae 和 V. parahemolyticus 具有抑制作用,MIC 值分别为 31.25 µg/mL,62.5 µg/mL,62.5 µg/mL 和 125 µg/mL。Quest...
7-O-Methylaloeresin A
TN1332
7-O-Methylaloeresin A shows significant antioxidant activity, it also has moderate inhibitory active on BACE.
AM-6494
T10292
AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).
BACE1-IN-1
T10450
BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
Bavachromene
TN1434
Bavachromene exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.
Epiberberine chloride
T8306
Epiberberine chloride (Epiberberine (chloride)) 是一种从黄连中得到的生物碱,是一种AChE 和BChE 抑制剂,和非竞争性的BACE1抑制剂。它具有抗氧化作用,能够清除 ONOO-,可用于研究阿尔滋海默症和糖尿病。
BACE1-IN-4
T10452
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.
PF-06751979
T12429
PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
Kushenol C
TN4399
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
BACE1-IN-5
T10453
BACE1-IN-5 (Compound 15) 是一种 BACE1抑制剂,IC50为 9.1 nM。BACE1-IN-5还可抑制细胞 Aβ,IC50为 0.82 nM。并且,BACE1-IN-5 具有改善 hERG 抑制和 P-gp 外排的药物化学作用。
BACE1-IN-2
T10451
BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).
LY2886721
T6058
LY2886721 是选择性的,口服活性的 β 位淀粉样蛋白前体蛋白裂解酶 1 抑制剂,对重组人 BACE1的 IC50=20.3 nM。它对 BACE1的选择性高于对组织蛋白酶 D、胃蛋白酶、肾素的选择性,但缺乏对 BACE2的选择性。它可透过血脑屏障,并可用于研究阿尔茨海默氏病。
AZD3839 free base
T6772
AZD3839 free base 是一种具有口服活性的、选择性的、可透过大脑屏障的BACE1抑制剂 (Ki=26 nM),对 BACE2 和组织蛋白酶 D 的选择性分别为 14 倍和 >1000 倍。在小鼠、豚鼠和非人灵长类动物中,它剂量和时间依赖性的降低血浆、脑和脑脊液 Aβ 水平,可用于研究阿尔茨海默病。
LX2343
T4398
LX2343 是一种非 ATP 竞争性 PI3K 抑制剂,IC50 为 15.99±3.23 μM。它是一种 BACE1 酶抑制剂,IC50 值为 11.43±0.36 μM。它在促进 Aβ 清除中刺激自噬。
SEW06622
T83616
SEW06622 是一种有效的 乙酰胆碱酯酶(AChE)和β-分泌酶-1(BACE-1)抑制剂,是治疗阿尔茨海默病的潜在候选化合物。
8-Geranyloxypsoralen
TN1343
8-Geranyloxypsoralen 是一种呋喃香豆素,分离自葡萄柚,是 P450 3A4 的有效抑制剂(IC50:3.93 μM)。
Aloeresin D
T8179
Aloeresin D 是一种从芦荟中分离得到的色原酮苷,能够抑制 β-分泌酶活性,IC50=39 μM。
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