tetramer

Magnesium Lithospermate B 是一种咖啡酸四聚体的衍生物，从Salviae miltiorrhizae 中提取得到。它能够抑制神经炎症并减轻神经变性。它被广泛用于心血管疾病的研究，并且可以防止葡萄糖引起的细胞内氧化损伤。

Aurothiomalate tetramer sodium，作为Aurothiomalate sodium的四聚体形态，属于抗关节炎的金制剂。这种化合物是强效且具选择性的致癌PKCι信号抑制剂。

RUNX1 ETO tetramerization-IN-1 is a small-molecule inhibitor that specifically targets NHR2 of RUNX1 ETO, effectively inhibiting the tetramerization process. With an EC50 value of 0.25 μM, this compound successfully restores gene expression that has been down-regulated by RUNX1 ETO. Furthermore, RUNX1 ETO tetramerization-IN-1 demonstrates promising anti-leukemic activity by inhibiting the proliferation of SKNO-1 cells dependent on RUNX1 ETO and significantly reducing RUNX1 ETO-associated tumor growth in a mouse model [1] [2] [3].

Pulcherosine是一种通过isodityrosine和tyrosine的氧化偶联形成的化合物，具有构成2,2'-dihydroxy-3-phenoxybiphenyl芳香核心的联苯键。它在isodityrosine转化为四聚体di-isodityrosine的过程中充当中间体。此外，Pulcherosine还参与形成多肽间的交联和 或大范围的多肽内环。

Insulin β Chain Peptide (15-23), also referred to as INS, is an insulin-derived peptide that is specifically recognized by islet-associated T cells. The tetramer of Insulin β Chain Peptide (15-23) effectively stained the INS-reactive CTL clone G9C8; however, neither this tetramer nor the negative control tetramer (TUM) exhibited staining on the splenic CD8+ T cells obtained from NOD or 8.3-TCRαβ transgenic NOD mice.

ZINC08383544 is a specific pyruvate kinase M2 activator which promotes the formation of PKM2 tetramer. ZINC08383544 effectively blocks PKM2 nuclear translocation, and inhibits the growth of tumor.

GUN35758, also known as 4'-Carboxybenzo-18C6, is a novel transthyretin (ttr) amyloidogenesis inhibitor, stabilizing the ttr tetramer by binding to the allosteric sites on the molecular surface of the ttr tetramer. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https: www.medkoo.com page naming).

TRAP1-IN-2（化合物36）作为TRAP1下游蛋白的选择性降解剂，不会对Hsp90的胞质下游蛋白产生影响。同时，该化合物还能抑制OXPHOS，导致细胞糖酵解代谢的变化。此外，TRAP1-IN-2会破坏TRAP1四聚体的稳定性，并影响线粒体膜电位。

Streptavidin（链霉亲和素）是从细菌中纯化出来的蛋白四聚体，对生物素具有非常高的亲和力，常用于纯化或检测各种生物分子。具有免疫活性，可抑制T细胞的IL-2 合成和 CD25 表达。

BI-0115 是LOX-1的选择性抑制剂，其IC50值为 5.4 µM，可以阻止细胞摄取氧化低密度脂蛋白。它通过形成同源二聚体配体结合域的二聚体来触发受体抑制。

Vitisin A ((+)-Vitisin A) 是一种可从 Vitis vinifera 根中分离出来的白藜芦醇四聚体，具有抗氧化、抗癌、抗细胞凋亡、神经保护和抗炎活性，可改善东莨菪碱诱导的失忆 ICR 小鼠的学习和记忆功能受损，可用于研究退行性疾病。