romk

VU591 hydrochloride 是选择性的肾外髓钾通道抑制剂，IC50为 0.24 μM。

VU591 是选择性的肾外髓钾通道抑制剂，IC50为 0.24 μM。

VU590 是一种具有高效性和中等选择性的肾外髓质钾 ROMK (Kir1.1) 抑制剂。VU590 抑制 Kir7.1，可调节子宫肌层收缩力和黑皮质素信号传导。

ROMK-IN-2 (compound 1) 是一种高效的肾外髓质钾 (renal outer medullary potassium (ROMK)) 抑制剂。

ROMK-IN-32 是一种肾外髓质钾通道 (ROMK) 抑制剂 (IC50: 35 nM)，也能够抑制 hERG (IC50: 22 μM)。

Psycholeine is isolated from the tropical plant Psychotria oleoides; exhibits somatostatin antagonistic activity on growth hormone secretion.

MK-7145 is an inhibitor of ROMK(IC50 of 0.045 μM).

12-Ketodeoxycholic acid 是一种胆汁酸，由肾脏代谢产生。它是肾脏损伤的标志物。

Lipopolysaccharides, from Klebsiella pneumoniae (LPS, from bacterial (Klebsiella pneumoniae)) 是一种来源于肺炎克雷伯杆菌的脂多糖内毒素和TLR4激活剂，属于S型LPS。Lipopolysaccharides, from Klebsiella pneumoniae 具有典型的三部分结构：O抗原、核心寡糖以及脂质A。该化合物可能在细菌免疫逃逸中起作用，通过抑制补体介导的杀伤作用和宿主抗菌肽的分泌，使细菌能够逃脱免疫防御。此化合物具有高滞粘性和抗血清杀伤特性，并可能引发脓毒症。Lipopolysaccharides, from Klebsiella pneumoniae 常用于构建动物败血症/脓毒症模型。

PF-06807656 is insensitive to the introduction of the N171D mutation in the ROMK conduction pore that greatly diminishes the activity of other small-molecule inhibitors. PF-06807656 is an effective ROMK inhibitor (Tl+ flux IC50 = 160 nM).

MK-8153 是一种选择性的、有效的、口服具有活力的肾外髓质钾通道 (ROMK) 抑制剂，作用于 ROMK EP (IC50: 5 μM) 和 hERG EP (IC50: 34 μM)。MK-8153 能够用作利尿剂。

XAN35021, also known as ROMK inhibitor 25, or ROMK-IN-25, is a potent and selective ROMK inhibitor with improved pharmacokinetic properties. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

BMS-986308 是一种选择性强且口服活性的肾外髓质钾 (ROMK) 通道抑制剂，对 ROMK 的选择性优于 hERG，可用于心力衰竭研究。