rat bone marrow

PF-06446846 是口服有活性的 PCSK9抑制剂。它能够在密码子区域附近阻断 80S ribosome，选择性地直接抑制 PCSK9 的翻译。

AZD2906, a selective glucocorticoid receptor (GR) agonist, demonstrates inhibitory concentrations (IC50s) of 2.2 nM in human GR, 0.3 nM in rat peripheral blood mononuclear cells (PBMC), 41.6 nM in human whole blood, and 7.5 nM in rat whole blood, respectively[1]. Additionally, it induces an increase in micronucleated immature erythrocytes within rat bone marrow.

BI-9740 是一种口服活性的选择性 Cathepsin C (CatC) 抑制剂，其在小鼠中的IC50为0.6 nM，在大鼠中为2.6 nM。BI-9740 能抑制活性中性粒细胞弹性蛋白酶的产生，并降低大鼠骨髓中性粒细胞弹性蛋白酶和 Cathepsin G 的活性。此化合物可减轻心脏移植后的病理损伤，缩短复跳时间，改善左心室功能，适用于器官移植研究。

Imiprothrin 是一种诱导CYP1A2和金属硫蛋白 1a表达的化合物，具有显著的遗传毒性及细胞毒性。它在大鼠肝细胞中能引发这两个基因的过表达，启动解毒反应。Imiprothrin 能诱导大鼠骨髓细胞染色体畸变和微核形成，并损害肝细胞 DNA。该化合物在大鼠体内诱导氧化应激，导致脂质过氧化、活性氧增加和氧化还原失衡，损害肝肾功能并引发组织损伤。Imiprothrin 可抑制小鼠体重增长，高剂量下甚至增加雌性小鼠的死亡率，但在大鼠实验中未显示致癌性；天冬氨酸氨基转移酶和总蛋白被识别为敏感性毒性生物标志物。

The prostaglandin E receptor 4 (EP4) is one of four G protein-coupled receptors that mediate the actions of prostaglandin E2 . Binding of PGE2 to the EP4 receptor causes an increase in intracellular cyclic AMP, which plays important roles in bone formation and resorption, cancer, and atherosclerosis. KMN-80 is a substituted γ-lactam (pyrrolidinone) derivative of PGE1 that acts as a selective and potent agonist of EP4 with an IC50 value of 3 nM (IC50 = 1.4 μM for EP3 and > 10 μM for all other prostanoid receptors). In functional assays it has been shown to stimulate secreted alkaline phosphatase gene reporter activity in EP4-transfected HEK293 cells with an EC50 value of 0.19 nM, demonstrating >5,000 and 50,000-fold selectivity against EP2 and TP, respectively. KMN-80 can induce the differentiation of bone marrow stem cells from both young and aged rats into osteoblasts in vitro (EC50s = 20 and 153 nM, respectively) and exhibits favorable tolerability up to at least 10 μM, whereas the EP4 agonist L-902,688 is highly cytotoxic at similar concentrations in these cells. KMN-80 has been used to repair calvarial defects in an in vivo rat craniomaxillofacial reconstruction model (rate of reduction in defect size equivalent to BMP-2 treated rats) and to promote bone formation in a rat incisor tooth socket model.

Gigantol 是一种联苄基化合物，从几种药用兰花中获得，是一种Wnt/β-catenin 通路抑制剂，具有抗肿瘤活性。

Dendrobium phenol (Standard) 是 Dendrobium phenol 的标准品。适用于定量分析、质量控制及生化实验等相关研究。Gigantol 是一种联苄基化合物，从几种药用兰花中获得，是一种Wnt/β-catenin 通路抑制剂，具有抗肿瘤活性。