Imiprothrin is an inducer of CYP1A2 and metallothionein 1a, exhibiting significant genotoxicity and cytotoxicity. In rat hepatocytes, it triggers detoxification responses by upregulating these genes. Imiprothrin induces chromosomal aberrations and micronucleus formation in rat bone marrow and causes DNA damage in liver cells. It leads to oxidative stress in rats, resulting in lipid peroxidation, excessive reactive oxygen species, and redox imbalance, subsequently impairing liver and kidney function and causing tissue damage. Imiprothrin inhibits weight gain in mice and, at high doses, significantly increases mortality in female mice. However, it shows no carcinogenic properties in rat studies, where aspartate aminotransferase and total protein are identified as sensitive toxicity biomarkers.

炔咪菊酯