ra 9

RA-9 是一种高选择性蛋白酶体相关的 DUBs 抑制剂，具有良好的毒性和抗癌活性。它阻断泛素依赖性蛋白降解而不影响 20S 蛋白酶体蛋白水解活性。它诱导卵巢癌细胞内质网应激反应，选择性诱导卵巢癌细胞株和供体原代培养细胞凋亡。

1-bromo-5-hydroxyanthra-9,10-quinone 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131407。

NPY 5RA972 是一种神经肽 Y Y5 受体拮抗剂

KIRA9 是 IRE1 的有效抑制剂，对 INS-1 细胞的 IC50 值为 4.8 μM。KIRA9 可以完全结合 IRE1 的 ATP 结合位点，并阻断内质网 (ER) 定位的 mRNA 衰减和细胞凋亡 (apoptosis)。

2,3,5,6-Tetra(9H-carbazol-9-yl)terephthalonitrile 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64401。

2,4,5,6-Tetra(9H-carbazol-9-yl)-1,3-Dicyanobenzene 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T64416，CAS号为 1416881-52-1。

SS148 is an nsp14 nsp16 MTase inhibitor. It also showed some degree of selectivity against human protein MTases, an indication of great potential for chemical optimization towards more potent and selective inhibitors of coronavirus MTases.

ent-17-Hydroxykaura-9(11),15-dien-19-oic acid is a natural product from Wedelia trilobata.

Atorvastatin ethyl ester, a derivative of Atorvastatin, exhibits potent inhibition of 9-cis-RA-induced Gal4 reporter activity.

Atorvastatin methyl ester is a derivative of Atorvastatin. It inhibits the 9-cis-RA-induced Gal4 reporter activity more strongly than Atorvastatin.

Tarenflurbil ((R)-Flurbiprofen) 是 Flurbiprofen 的 R 型对映体，可抑制 [3H]9-cis-RA 结合到 RXRαLBD，IC50为 75 μM。它可研究阿尔兹海默症。

AGN 193109 is a potent antagonist of retinoic acid receptors (RARs; Kd= 2, 2, and 3 nM for RARα, β, and γ, respectively), exhibiting selectivity for RARs over retinoid X receptors (RXRs; Kd= >10,000 nM for human RXRα, β, and γ receptors). This compound effectively reverses cellular morphology changes and growth suppression induced by RAR agonists such as all-trans-RA, 13-cis-RA, and 9-cis-RA in ECE16-1 human endometrial ectocervical epithelial cells, particularly when used at a 10-fold molar excess. Furthermore, AGN 193109 downregulates the expression of cytokeratin K5-8, 13, 14, 16, 17, and 19 genes, indicating inhibition of retinoid action, specifically when co-administered with TTNPB but not as a standalone treatment. In vivo studies demonstrate teratogenic effects, including cleft palate, frontonasal dysplasia, and eye malformations in mouse fetuses following a single oral dose of 1 mg kg.