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Anti-IL-1RA Antibody (9J104)

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Anti-IL-1RA Antibody (9J104)
产品编号 TMAY-00306
别名 interleukin 1 receptor antagonist

Anti-IL-1RA Antibody (9J104) 是一种 Rabbit 抗体，靶向 IL-1RA。Anti-IL-1RA Antibody (9J104) 可用于 ELISA。

Anti-IL-1RA Antibody (9J104)
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Anti-IL-1RA Antibody (9J104)

Rating icon 还可以
Anti-IL-1RA Antibody (9J104)
产品编号 TMAY-00306 别名 interleukin 1 receptor antagonist

Anti-IL-1RA Antibody (9J104) 是一种 Rabbit 抗体，靶向 IL-1RA。Anti-IL-1RA Antibody (9J104) 可用于 ELISA。

规格价格库存数量
100 μL
¥ 2,289
5日内发货
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产品介绍

生物活性
产品描述
Anti-IL-1RA Antibody (9J104) is a Rabbit antibody targeting IL-1RA. Anti-IL-1RA Antibody (9J104) can be used in ELISA.
别名interleukin 1 receptor antagonist
Ig Type
Rabbit IgG
克隆号
9J104
交叉反应
Human
应用
ELISA
推荐剂量
ELISA: 1:5000-1:10000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human IL1RA (rh IL1RA; TMPY-00853; NP_776214.1; Arg 26-Glu 177) .
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A), and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. A polymorphism of this protein-encoding gene is reported to be associated with an increased risk of osteoporotic fractures and gastric cancer. IL-1RA/IL1RN may inhibit the activity of IL-1 by binding to its receptor and it has no IL-1 like activity. Genetic variation in IL-1RA/IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Defects in IL-1RA/IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA) which is also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis, and pustulosis from birth.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human IL1RA protein (TMPY-00853)
抗原种属
Human
研究领域
Neuroinflammation
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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