pc 4

Phytochelatin 4（PC 4）一种由谷胱甘肽衍生的多肽和重金属解毒剂 螯合剂，由4个单位的glu - cys组成和由PC合成酶生成，对Cd（cadmium）具有耐受性，与重金属络合后被封存在液泡内。

Silicon Phthalocyanine 4 is a drug with anti-cutaneous neoplasms activity.

PC Methyltetrazine-PEG4-NHS carbonate ester is a polyethylene glycol (PEG) derived linker specifically designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

PC-Biotin-PEG4-PEG3-azide is a cleavable 7-unit polyethylene glycol (PEG) antibody-drug conjugate (ADC) linker employed for the synthesis of ADCs [1].

PC DBCO-PEG4-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

PC Alkyne-PEG4-NHS ester is a cleavable 4-unit PEG linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].

Biotin-PEG4-PC-PEG4-alkyne is a polyethylene glycol (PEG)-based proteolysis targeting chimera (PROTAC) linker utilized in the synthesis of PROTACs[1].

6-(1-Hydroxypentyl)-4-methoxy-2H-pyran-2-one. PC 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T130784。

PC-Biotin-PEG4-NHS carbonate is a polyethylene glycol (PEG) derived linker employed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Opc 4392 is an agonist of presynaptic dopamine D(2) receptor.

OPC 4392 hydrochloride 作为突触前多巴胺受体 (dopamine receptor) 的激动剂以及突触后D2受体的拮抗剂，具有显著的生物活性。该化合物能有效逆转由Reserpine引起的多巴胺积累，并在Apomorphine诱导的小鼠模型中抑制刻板行为和攀爬行为。

Tolvaptan (OPC-41061) 是一种可口服的选择性精氨酸加压素受体 2 拮抗剂，可用于治疗低钠血症。

Englerin A 是一种具有选择性和高效性的 TRPC4 和 TRPC5 通道激动剂，是一种来自东非植物 Phyllanthus engleri 的小分子化合物，具有镇痛、抗炎和抗癌活性。Englerin A 可刺激 TRPC4 C5 阳离子通道以抑制肿瘤细胞系增殖，诱导人肾癌细胞坏死。

GFB-8438 是有效的TRPC5选择性抑制剂，对 hTRPC5 和 hTRPC4 的IC50分别为 0.18 和 0.29 μM。它对 TRPC6、其他 TRP 家族成员、NaV1.5 具有良好的选择性，对 hERG 通道的活性也有限。它对小鼠足细胞的保护作用。

HC-070是一种 TRPC5和 TRPC4拮抗剂（IC50 = 9.3 nM 和46 nM）。

Phytochelatin 4 (PC 4) TFA，一种在植物中发现的短肽，富含 Cys，且具有 γ-Glu-Cys 基序。

DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1]. DP-C-4 (1-50 μM; 24 hours) has degradation effects on EGFR and PARP simultaneously in a dose-dependent manner in SW1990 cells[1]. [1]. Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 May 26.

PC407-ws is a water-soluble novel COX-2 inhibitor.

VPC44116 is a bioactive chemical.

TRPC4 5-IN-1 可用于研究皮肤炎性疾病和蛋白尿肾病。它是 TRP 通道 5 4 (TRPC5 4) 的有效抑制剂，IC50值分别为 0.54 μM 和2.06 μM。

TRPC4 5-IN-3 (Compound 32) 是一种口服有效的瞬时受体电位经典通道 4 5（TRPC4 5）抑制剂，其IC50值分别为 3.6 nM 和 5.5 nM。此外，TRPC4 5-IN-3 能够抑制 hERG 通道，IC50为 6.5 µM。该化合物在人类、鼠类和小鼠的肝微粒体中体现了良好的代谢稳定性。在小鼠模型中，TRPC4 5-IN-3 表现出显著的抗抑郁和抗焦虑活性，并且在小鼠体内展现出良好的药代动力学特性，口服生物利用度达到 87%。

TRPC5-IN-4 是一种有效且安全的TRPC 抑制剂，对TRPC5和TRPC4的IC50分别为 14.07 nM 和 65 nM。TRPC5-IN-4 对肝、肾细胞成分无损伤。TRPC5-IN-4 可用于慢性肾脏病的研究 (CKD)。

Deserpidine hydrochloride is the salf form of Deserpidine (free base), which is an antihypertensive drug related to reserpine which occurs naturally in Rauwolfia canescens. Deserpidine is a competitive inhibitor of the angiotensin converting enzyme (ACE). By competing with angiotensin I for ACE, deserpidine blocks the conversion of angiotensin I to angiotensin II, which is a potent vasoconstrictor. Reduced level of serum angiotensin II causes a decrease in blood pressure. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex.

M&B 39279 is a potent inhibitor of plant, yeast and mouse protoporphyrinogen oxidase.