MSG606 TFA, a potent antagonist of the human MC1 receptor (IC50 = 17 nM), functions as a partial agonist at the human MC3 and MC5 receptors (EC50 values of 59 and 1300 nM, respectively). It demonstrates binding affinity for A375 melanoma cells in vitro and selectively reverses induced hyperalgesia in female mice without affecting male mice.
Pregnant mare serum gonadotropin (PMSG) 是用于促进动物卵泡发育及排卵的促性腺激素。该激素可通过激活体内的血液激素、促性腺激素以及前脑垂体和下丘脑中的细胞质雌二醇受体,调节相关生理过程。在畜牧业中,Pregnant mare serum gonadotropin 用以增加繁殖效率;此外,它也被应用于研究发情周期的调节。