metabolic disorder

Entacapone 是一种有效且特异性的外周儿茶酚-O-甲基转移酶 （COMT） 抑制剂，其IC50值为151 nM。Entacapone也是一种潜在的肥胖相关基因 （FTO）抑制剂，可以抑制FTO 去甲基化活性并应用于代谢疾病的研究。

Nequinate 是一种喹啉化合物，是一种抗球虫剂，可预防球虫病。它抑制黄嘌呤氧化还原酶活性。

N-Acetyl-L-arginine (Ac-Arg-OH) 是一种胍基诺化合物，被发现存在于血液渗析性肾不足儿童患者血清中的。

Ethyl cinnamate 是食品香料和化妆品添加剂，也是哺乳动物组织的优良清除剂。

TXNIP-IN-1 是硫氧还蛋白-硫氧还蛋白相互作用蛋白复合物抑制剂。它在 TXNIP-TRX 复合物相关代谢紊乱的糖尿病、心血管疾病或炎症疾病方面有研究的价值。

Galactosylcerebrosides are glycosphingolipids that contain a galactose attached to a ceramide acylated with a hydroxy or non-hydroxy fatty acid. They are metabolic precursors to sulfatides , found primarily in nerve tissues, and are the main glycosphingolipids in the central nervous system. Galactosylcerebrosides are involved in a multitude of cellular processes including cell agglutination, cellular signaling in glycosynapses, cellular development, and activation of T cells. They accumulate in globoid cells in the brain of patients with Krabbe disease, a disorder characterized by a deficiency in galactosylcerebrosidase activity. This product is a mixture of isolated bovine hydroxy galactosylcerebrosides.

Galactosylcerebrosides are glycosphingolipids that contain a galactose attached to a ceramide acylated with a hydroxy or non-hydroxy fatty acid. They are metabolic precursors to sulfatides , found primarily in nerve tissues, and are the main glycosphingolipids in the central nervous system. Galactosylcerebrosides are involved in a multitude of cellular processes including cell agglutination, cellular signaling in glycosynapses, cellular development, and activation of T cells. They accumulate in globoid cells in the brain of patients with Krabbe disease, a disorder characterized by a deficiency in galactosylcerebrosidase activity. This product is a mixture of isolated bovine non-hydroxy galactosylcerebrosides.

L-Glyceric acid sodium is a urinary metabolite predominantly found in individuals with the rare inherited metabolic disorder, L-glyceric aciduria. This compound serves as a diagnostic tool for identifying primary hyperoxaluria type 2 (PH2) and can be used to differentiate between PH1 and PH2 based on its excretion pattern.

Tiludronate (Tiludronic Acid) disodium hemihydrate is an orally active bisphosphonate compound that functions as an osteoregulator. It is primarily utilized in metabolic bone disorder research. This compound acts as a potent inhibitor of the osteoclast vacuolar H+ -ATPase and possesses antiresorptive and anti-inflammatory properties[4].

Trimyristin (Tritetradecanoin) 是一种 Myristica fragransHoutt 的有效成分，能够显著抑制乙酰胆碱酯酶 (AChE)，酸性和碱性磷酸酶 (ACP ALP) 特性。它对 AChE，ACP 和 ALP 的 IC50分别为 0.11、0.16 和 0.18 mM。

2-Methylsuccinic acid (Pyrotartaric Acid) 是乙基丙二酸脑病的主要生化指标，是人体液中的正常代谢物。

JBSNF-000028 TFA是一种口服活性烟酰胺N-甲基转移酶(NNMT)抑制剂，其IC50值针对人NNMT (hNNMT)、猴NNMT (mkNNMT) 和小鼠NNMT (mNNMT) 分别为0.033 μM、0.19 μM和0.21 μM。

PI5P4Kα-IN-1（化合物13）是一种针对PI5P4Kα和PI5P4Kβ具有选择性抑制作用的化合物（IC50分别为2 μM和9.4 μM）。它适用于癌症、代谢和免疫紊乱相关研究。

3-Methyl-L-histidine 是一种肉类尤其是鸡肉摄入和大豆制品摄入的生物标记。

Propionicacid-d5 是 Propionicacid 的氘代化合物。Propionicacid 的 CAS 号为 79-09-4。Propionic acid 被广泛用作食品中的抗真菌剂。它以低水平天然存在于乳制品中，并与其他短链脂肪酸 (SCFA) 一起普遍存在于人类和其他哺乳动物的胃肠道中，作为微生物消化碳水化合物的最终产物。在动物体内有显着的生理活性。

Propionic-2,2-d2 acid 是 Propionic acid 的氘代化合物。Propionic acid 的 CAS 号为 79-09-4。Propionic acid 被广泛用作食品中的抗真菌剂。它以低水平天然存在于乳制品中，并与其他短链脂肪酸 (SCFA) 一起普遍存在于人类和其他哺乳动物的胃肠道中，作为微生物消化碳水化合物的最终产物。在动物体内有显着的生理活性。

21-Deoxy Cortisone (21-Desoxycortisone; NSC 38722)为11-酮孕酮的一种皮质类固醇代谢产物。该化合物通过11-酮孕酮经细胞色素P450 (CYP)酶CYP17A1的作用生成，也可由21-脱氧皮质醇通过11β-羟基类固醇脱氢酶2型 (11β-HSD2) 的氧化反应形成。在先天性肾上腺增生症患者中，由于缺乏21-羟化酶，21-Deoxy Cortisone 的水平会出现上升，此症状为该遗传代谢缺陷的表现之一。

(R)-3-Hydroxyisobutyric acid sodium 是 3-羟基异丁酸尿症的生物化学标记，此代谢异常以尿液中该化合物浓度升高为特征。