mbl 2

CHEMBL241987 靶向腺苷受体 A3（人）。

EBL-3183为一种吲哚-2-羧酸盐，作为有效的金属-β-内酰胺酶(MBL)抑制剂。它通过可逆结合、非共价及竞争性作用抑制NDM-1，其pIC50值为7.7。

Metallo-β-lactamase-IN-15 (Compound ±13) 作为一种MBL抑制剂，展现出对NDM-1、IMP-1 及 VIM-2 的卓越抑制效果，其IC50值分别为0.29 μM、0.088 μM 和 0.063 μM。

Metallo-β-lactamase-IN-6 is a highly effective inhibitor of VIM-Type metallo-β-lactamase, demonstrating IC 50 values of 0.56 μM, 29.50 μM, and 5.78 μM for VIM-2, VIM-1, and VIM-5, respectively. In addition, Metallo-β-lactamase-IN-6 exhibits potent synergistic antibacterial properties when combined with Meropenem, particularly against engineered Escherichia coli strains and clinically isolated Pseudomonas aeruginosa carrying the VIM-2 MBL gene [1].