machinery

CID-1067700 是泛 GTPase 抑制剂，可竞争性抑制 Ras-related in brain 7 (Rab7) 中的 Ras 相关蛋白，Ki 为 13 nM。

PC58538 is an inhibitor of FtsZ protein, a important role in the division machinery of bacterial cells.

CEM114 is a potent chemical compound known as a chemical epigenetic modifier (CEM). It functions by employing CRISPR-Cas9 systems to harness endogenous chromatin machinery, thereby exerting its epigenetic modifying effects.

Zosurabalpin（Abx MCP）是一种大环肽类抗生素，对于耐药性的革兰氏阴性菌有效，如碳青霉烯类耐药鲍曼不动杆菌（CRAB），能够结合并阻断用于转运外膜脂多糖的蛋白质机器复合物LptB2FGC。

DC271作为RAR激动剂，属于类视黄醇类，能够激发与内源性类视黄醇ATRA及合成类视黄醇EC23相一致的细胞反应。此化合物通过与类视黄醇相关蛋白（例如CRABPII）结合，实现内源性类视黄醇ATRA的细胞核易位作用。

PAN endonuclease-IN-1 (Compound 23) 是一种针对 PAN 内切酶的有效抑制剂，具有对 WT、I38T 和 E23K 各型号 PAN 内切酶展现出的 Kd 值分别为 277 μM、384 μM 和 328 μM。 作为 RNA 依赖的 RNA 聚合酶 N 端内切酶的抑制剂，此化合物对于流感病毒复制机制中的关键组成部分，即抗病毒靶点，具有重要作用。

Neochamaejasmin A can inhibit cellular (3)H-thymidine incorporation (IC 50 12.5 microg/mL) and subsequent proliferation of human prostate cancer LNCaP cells, it blocks cell cycle progression at the G1 phase by activating the p21 protein and ultimately pro

Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regu