hd 6

FHD-609 为含溴结构域蛋白BRD9的抑制剂及降解剂，针对ncBAF，适用于研究含BAF复合亚基突变的多种癌症。FHD-609与Telomelysin或INO5401联用，或对肾上腺皮质癌(ACC)的研究具有潜在作用。

gamma-HCH-d6 是 gamma-HCH 的氘代化合物。gamma-HCH 的 CAS 号为 319-86-8。

Thiabendazole NH-d6 是 Thiabendazole NH 的氘代化合物。Thiabendazole NH 的 CAS 号为 148-79-8。Thiabendazole 是具有驱虫特性的苯并咪唑衍生物。

β-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth ofB. adolescentis,L. acidophilus,B. breve,B. vulgatus,L. fermentum,B. longum, andS. thermophilusin an antimicrobial radial diffusion assay.2β-Defensin-1 also inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius, and of susceptibleM. tuberculosisH37Rv but not of resistantM. tuberculosisRM22 when used at a concentration of 128 μg/ml.3,4It blocks human and mouse Kv1.3 voltage-gated potassium channels (IC50s = 11.8 and 13.2 μM, respectively).5Overexpression of β-defensin-1 in the human oral squamous cell carcinoma (OSCC) cell lines HSC-3, UM-1, and SCC-9 increases migration and invasion but not proliferation.6 1.Lehrer, R.I.Primate defensinsNat. Rev. Microbiol.2(9)727-738(2004) 2.Schroeder, B.O., Ehmann, D., Precht, J.C., et al.Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptideMucosal Immunol.8(3)661-671(2015) 3.Ouhara, K., Komatsuzawa, H., Yamada, S., et al.Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, β-defensins and LL37, produced by human epithelial cellsJ. Antimicrob. Chemother.55(6)888-896(2005) 4.Fattorini, L., Gennaro, R., Zanetti, M., et al.In vitro activity of protegrin-1 and beta-defensin-1, alone and in combination with isoniazid, against Mycobacterium tuberculosisPeptides25(7)1075-1077(2004) 5.Feng, J., Xie, Z., Yang, W., et al.Human beta-defensin 1, a new animal toxin-like blocker of potassium channelToxicon113(2016) 6.Han, Q., Wang, R., Sun, C., et al.Human beta-defensin-1 suppresses tumor migration and invasion and is an independent predictor for survival of oral squamous cell carcinoma patientsPLoS One9(3)e91867(2014)

ED11是一种具有高效选择性的caspase-6抑制剂，IC50为12.12 nM。它通过与Htt竞争caspase-6的活性位点，减少Htt的裂解。ED11能够穿越血脑屏障 (BBB)，在亨廷顿氏病 (HD) 研究中具有潜在应用价值。