d16:1

C16 Sphingosine-1-phosphate (C16 S1P) is a derivative of sphingosine-1-phosphate that binds to S1P1/EDG-1, S1P3/EDG-3, and S1P2/EDG-5 receptors with affinities of 115%, 83%, and 103%, respectively, relative to S1P in CHO cells. C16 S1P was increased in postmortem primary open angle glaucoma trabecular meshwork samples.

Sphingosine (d16:1), an unconventional sphingolipid, is synthesized through enzymatic reactions starting with the condensation of myristoyl-CoA and serine by serine palmitoyltransferase long-chain base subunit 3 (SPTLC3), which shows a preference for myristoyl-CoA. This compound is found in minute quantities in its free form in human plasma and as a component of various plasma sphingolipids, such as sphingosine-1-phosphate, ceramides, sphingomyelins, and in brain cerebrosides, albeit at lower concentrations than the more common d18:1 sphingoid base. Sphingosine (d16:1) acts as an inhibitor of PKC in mixed micelle assays and diminishes superoxide production triggered by phorbol 12-myristate 13-acetate in isolated human neutrophils, as well as inhibiting the growth of CHO cells with IC50 values of 1 and 3.2 µM, respectively. Additionally, the concentration of sphingolipids containing sphingosine (d16:1) in the plasma is linked to the dietary consumption of saturated fatty acids and protein among ethnic Chinese populations.

C16 Ceramide (d16:1, C16:0) 是一种具有生物活性的鞘脂，能够在棕榈酰磷脂 (POPC) 双层中诱导富含棕榈酰鞘磷脂结构域的有序相和凝胶相的形成及其热稳定性。此化合物存在于人红细胞鞘磷脂中。

CD161 is a potent, selective, and orally bioavailable BET bromodomain inhibitor (IC50s: 28.2 nM and 7.2 nM for BRD4 BD1 and BRD4 BD2) with good anticancer activity.

ZD-1611 is an effective and selective ETA receptor antagonist. It is used for the research of ischemic stroke.

PD-161570 是一种有效的 ATP 竞争性人 FGF-1 受体抑制剂，IC50 为 39.9 nM，Ki 为 42 nM。它还是骨形态发生蛋白 (BMPs) 和TGF-β信号抑制剂。它抑制PDGF 刺激的自磷酸化和FGF-1受体磷酸化，IC50分别为 450 和 622 nM。它抑制 PDGFR、EGFR 和 c-Src 酪氨酸激酶，IC50 值分别为 310、240 和 44 nM。

CID16197121 is a bioactive chemical.

EIDD-1619 is a novel water-soluble analog of progesterone.

PD 161182 is a bioactive chemical.

DD-161515 is a VR1 antagonist.

Palmitic acid-16,16,16-d3 是 Palmitic acid 的氘代化合物。Palmitic acid 的 CAS 号为 57-10-3。Palmitic acid 是在动物、植物和微生物中发现的最常见的饱和脂肪酸，具有抗肿瘤活性。它可诱导小鼠颗粒细胞中葡萄糖调节蛋白 78 和 CCAAT 增强子结合蛋白同源蛋白的表达。

(10alpha)-16alpha,17,19-Trihydroxykaurane-18-oic acid is a natural product

Anticanceragent 168（compound d16）是一种DNA2抑制剂。该化合物能够促进细胞凋亡（apoptosis），引起细胞周期在S期显著停滞，并在含mutp53肿瘤中显示出抗癌效应，有助于克服化疗耐药性。