bzr

Ro15-4513 is imidazobenzodiazepinone derivative and is a partial inverse agonist of benzodiazepine receptors. Ro15-4513 is an effective ethanol antagonist.

Bz-RS-ISer(3-Ph)-Ome (Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate) 是紫杉醇衍生物，在低细胞毒性下抑制 HSV 复制周期，阻断 Vero 细胞的有丝分裂，影响 M-MSV 诱导的肿瘤大小，并通过抑制 PHA 诱导的 T 淋巴细胞增殖而影响免疫应答。

Bz-rA Phosphoramidite is used for ribonucleotides modification[1]. [1]. Elise Malek-Adamian, et al. 4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing. J Am Chem Soc. 2017 Oct 18;139(41):14542-14555.

5’-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.

Bz-rC Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.

5'-O-DMT-2'-O-TBDMS-Bz-rC, a modified nucleoside, is utilized in the synthesis of DNA or RNA.

5'-DMT-3'-TBDMS-Bz-rA is a nucleoside with protective and modification effects.

TCS 1105是一种GABAA 苯并二氮卓受体（BZR）配体。TCS 1105阻断Sema3A 诱导的轴突生长锥塌陷。TCS 1105能减少小鼠的焦虑样行为，增强攻击性行为和社会支配力。

GABA-IN-4 (Compound 17) 是一种 N-(indol-3-ylglyoxylyl)benzylamine 衍生物，其对 benzodiazepine receptor (BzR) [GABAA receptor 复合物中的结合位点] 具有高亲和力，Ki 值为 67 nM。Benzodiazepine 被广泛用于抗焦虑、镇静催眠和抗惊厥治疗。

Anxiolytic nonsedative agent-1 (TCS 1205) 是一种有效的选择性 GABAA 激动剂。Anxiolytic nonsedative agent-1 对牛脑膜中的 BzR 显示出明显的亲和力，对 α1β2γ2、α2β2γ2、α5β3γ2 的 Kis 分别为 14、121、239 nM。Anxiolytic nonsedative agent-1 在体外表现出 α2 选择性功效，在体内表现出抗焦虑选择性作用。