bms-8

BMS-8 抑制PD-1 PD-L1相互作用(IC50:7.2 μM)。它能够直接与 PD-L1 结合，促使形成 PD-L1 同源二聚体，进而阻断 PD-L1 与 PD-1 的相互作用。

BMS-817399 是一种具有口服活性的 CCR1 拮抗剂，具有结合亲和力和趋化性抑制效力的 IC50，可用于类风湿性关节炎的研究。

BMS-823778 是一种高效的 11β-羟基类固醇脱氢酶 1 型（11β-HSD-1）的抑制剂，可用于研究 2 型糖尿病。

(Rac)-BMS-816336 (Compound 6n) 是 BMS-816336 的外消旋体。(Rac)-BMS-816336 是人和小鼠 11β-羟类固醇脱氢酶 1 型 (11β-HSD1) 的有效抑制剂，其 IC50分别为 10 nM 和 68 nM，并具有良好的代谢稳定性 。

BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM and it also is selective and potent for CYP3A4 activity with an EC50 of 13 μM.

BMS-818251 是一种高效的HIV-1侵入性小分子抑制剂，其EC50为0.019 nM。相比于BMS-626529，BMS-818251在208-HIV-1毒株的交叉分支组上展示出超10倍的效力。该化合物通过与保守的β20-β21发夹结构中的gp120残基相互作用来增强效力。

BMS-833923 (XL-139) 是一种口服生物可利用的 Smoothened 拮抗剂，以剂量依赖性方式抑制 BODIPY cyclopamine 与 SMO 的结合，IC50为21 nM。

BMS-814580 is a potent and selective functional antagonist (Kb = 117 nM) of human MCHR1. BMS-814580 exhibits potent binding affinity (Ki = 17 nM) for human MCHR1. BMS-814580 also exhibits potent binding affinities for cynomolgus monkey and rat MCHR1 (Ki o

BMS-856 is a compound that inhibits the activity of 17beta-HSD3 enzyme.

BMS-813160 是CCR2 CCR5双重拮抗剂。有用于心血管的研究潜力。

BMS-820132 是一种葡萄糖激酶 (glucokinase) 激活剂 (AC50: 29 nM)。

BMS-870145 is a potent and selective P2Y1 purinergic receptor antagonist..

BMS-883559 is a novel inhibitor of the influenza nucleoprotein (INF-NP).

BMS-824 is a potent NS5A inhibitor. The 50% inhibition of HCV replicon replication for BMS-824 was approximately 5 nM, with a therapeutic index of >10,000. BMS-824 showed good specificity for HCV, as it was not active against several other RNA and DNA viruses.

BMS-830216 is a nonbasic melanin hormone receptor 1 antagonist and a prodrug of BMS-819881.

BMS-823778 hydrochloride为一种高效、选择性的口服11β-HSD1抑制剂，其对人11β-HSD1的IC50值为2.3 nM。

BMS 777607 (BMS 817378) 是 Met-related 抑制剂，能够抑制 c-Met (IC50:3.9 nM)，Axl (IC50:1.1 nM)，Ron (IC50:1.8 nM) 和 Tyro3 (IC50:4.3 nM) 的活性。

Alvespimycin hydrochloride (BMS 826476) 是一种Hsp90抑制剂，结合到 Hsp90，EC50为 62±29 nM。

N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Delcasertib (KAI-9803) 是一种有效且选择性的 δ-蛋白激酶 C (δPKC) 抑制剂，可改善急性心肌梗死动物模型的缺血再灌注损伤。

Fce 28260 is a 5 alpha-reductase inhibitor.

SC4 is a potent, direct AMPK activator. SC4 preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake.

CBL0100 is an inhibitor of viral transcriptional elongation, blocking both HIV-1 replication and reactivation.

AJ-108235 is a novel inhibitor of long chain fatty acid elongase 6 (ELOVL6).