anticancer agent 7

Anticancer agent 7 (Example 5) is an anti-cancer agent that exhibits potent anticancer activity against H1650 lung cancer cells, with an IC50 value of 5 μM.

Anticancer agent 73 是一种抗癌剂，它能有效地靶向反式激活反应（TAR）RNA 结合蛋白2（TRBP），并破坏TRBP-Dicer 的相互作用。Anticancer agent 73 通过调节 HCC 细胞中 miRNA 组和蛋白质组的表达谱，在体外和体内抑制 HCC 的生长和转移。

Anticancer agent 75 具有良好的抗疟原虫活性。Anticancer agent 75 是有效的抗癌剂，在癌细胞系中表现出细胞毒性和选择性。Anticancer agent 75 对正常人肾细胞系的细胞毒性比阿霉素标准品至少低 35 倍。

Anticancer agent 70 (Compound 21) is a potent anticancer compound that demonstrates remarkable cytotoxicity against multiple human cancer cell lines. It induces G0 G1-cell cycle arrest and concurrently elevates the levels of p53 and p21 proteins. Furthermore, Anticancer agent 70 induces ATP depletion and disruption of the mitochondrial membrane potential [1].

Anticancer agent 74 exhibits moderate anticancer activity with lower selectivity and cytotoxicity compared to doxorubicin towards normal cells [1].

Anticancer agent 72 (compound 8c) effectively inhibits the K+ channel, displaying significant potential as an anticancer treatment. Additionally, it induces apoptosis, a programmed cell death process [1].

Anticancer agent 78 具有抗芳香酶活性（IC50= 0.9 μM）。Anticancer agent 78 是一种有效的抗癌剂，显示细胞毒性。Anticancer agent 78 在乳腺癌中有研究潜力。

Anticancer agent 79 (compound 3d) 是一种抗癌化合物，具有良好的抗乳腺癌 (anti-breast cancer) 活性。Anticancer agent 79 对 T47-D 细胞表现出良好的细胞毒性活性（IC50= 13.64±0.26 μM）。

Anticancer agent 71 (Compound 4b) 是有效的抗癌剂。Anticancer agent 71 将细胞周期阻滞在 G2 M 期。Anticancer agent 71通过上调 Bax、Ikb-α 和切割 PARP 并下调 Bcl-2 表达水平诱导细胞凋亡。

Anticancer agent 77 表现出抗癌作用，能够广泛用于合成和药物化学方面的研究。

Anticancer agent 76 (Compound CT2-3) 是一种能够明显抑制人 NSCLC 细胞增殖、诱导细胞周期阻滞、ROS 生成和细胞凋亡（apoptosis）的抗癌剂。

Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) 具有抗菌、抗氧化作用，有选择性和敏感性的荧光特性，广泛用作食品添加剂。它对 HSV-1，水泡性口炎病毒和脊髓灰质炎病毒有显著的抗病毒作用。

Antiproliferative agent-22 是一种抗癌化合物，在 MCF-7、MDA-MB-231 和 MDA-MB-468 细胞上显示出抗增殖活性。Antiproliferative agent-22 可用于研究癌症。

Helichrysetin 是从豆蔻果实中分离出的一种天然产物，是一种 DNA 结合抑制剂，可抑制原位导管癌DCIS 的形成。它抑制细胞生长，可诱导 A549 细胞凋亡。

Antiproliferative agent-16 (Antiproliferative agent-16)是一种具有抗癌活性的吲哚酰肼-腙化合物。 Antiproliferative agent-16 对乳腺癌细胞表现出特异性 (对 MCF-7 细胞的 IC50 为 6.94 μM)。

Antiproliferative agent-59（Compound 14u）作为一种微管蛋白 (tubulin) 聚合抑制剂，显示了对多种癌细胞线如Huh7、SGC-7901 和 MCF-7的显著抗增殖效果，其 IC50 值分别为 0.03、0.18 和 0.13 μM。此化合物能在 G2 M 期阻断细胞周期，并在 Huh7 细胞中触发细胞凋亡 (apoptosis)。在 Huh7 异种移植小鼠模型中，Antiproliferative agent-59 对肝癌具备抗肿瘤活性，并未观察到显著的毒副作用。

Apoptosisinducer 30 (Compound 15a) 作为一种强效的抗癌化合物，特别通过线粒体途径促进MCF-7细胞的凋亡。它通过增加细胞内活性氧的水平和降低线粒体膜电位来实现其作用，并且使细胞周期在G0 G1期停滞。此外，Apoptosisinducer 30显著抑制细胞生长，其对MCF-7细胞的IC50为0.32 μM，并有效抑制小鼠乳腺癌模型中的肿瘤发展。

Antiangiogenic agent 7 (Compound 1) 主要通过诱导细胞凋亡、增加 Reactive Oxygen Species (活性氧)、以及抑制细胞内的酶硫氧还蛋白还原酶来发挥作用。此外，该化合物对多种癌细胞显示出较强的抗癌活性，具体包括宫颈癌细胞 HeLa，前列腺癌细胞 PC-3，与非小细胞肺癌细胞 A549，其 IC50 值范围为 0.08-3.5 μM。在小鼠异种移植模型实验中，Antiangiogenic agent 7 也能有效抑制肿瘤生长。

Anticanceragent 263 (compound 7) 是一种有效的抗癌剂，与 G-四链体 DNA (G4) 序列 22-mer Pu22 (c-MycDNA 的模拟物) 结合。作为结构调节剂，它显著增强蛋白质 α-螺旋的形成，并具备构建超分子网络的能力，同时不具有细胞毒性。

Antitumor agent-196 (Compound 6a (β, β, β)) 是一种青蒿素基础的低聚物，具有抗癌的特性，对 MCF-7 乳腺癌细胞(IC50 = 90 nM)表现出活性。它可通过调节 Bax-caspase 3 信号通路来诱导细胞凋亡 (Apoptosis)，并通过调控关键分子(如 GPX4)引发铁死亡 (Ferroptosis)。Antitumor agent-196 在癌症治疗研究中表现出应用潜力。

Anticanceragent 266 (Compound 3B) 是一种用于抑制肿瘤细胞增殖的抗癌剂，对 MCF-7 乳腺癌细胞系的 IC50 为 0.13 μM。

2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.32-deoxy-D-Glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B osteosarcoma cells cultured under hypoxic conditions when used at a concentration of 2 mg ml.4,5In vivo, 2-deoxy-D-glucose (500 mg kg) reduces tumor growth in 143B osteosarcoma and MV522 non-small cell lung cancer mouse xenograft models when used alone or in combination with doxorubicin or paclitaxel .6 1.Kang, H.T., and Hwang, E.S.2-Deoxyglucose: An anticancer and antiviral therapeutic, but not any more a low glucose mimeticLife Sci.78(12)1392-1399(2006) 2.Aft, R.L., Zhang, F.W., and Gius, D.Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: Mechanism of cell deathBr. J. Cancer87(7)805-812(2002) 3.Ralser, M., Wamelink, M.M., Struys, E.A., et al.A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growthProc. Natl. Acad. Sci. USA105(46)17807-17811(2008) 4.Liu, H., Savaraj, N., Priebe, W., et al.Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: A strategy for solid tumor therapy (Model C)Biochem. Pharmacol.64(12)1745-1751(2002) 5.Zhang, X.D., Deslandes, E., Villedieu, M., et al.Effect of 2-deoxy-D-glucose on various malignant cell lines in vitroAnticancer Res.26(5A)3561-3566(2006) 6.Maschek, G., Savaraj, N., Priebe, W., et al.2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivoCancer Res.64(1)31-34(2004)

Phosphoramide mustard cyclohexanamine（磷酰胺氮芥环己胺盐）是cyclophosphamide的活性代谢物，是一种交联DNA链的烷基化剂，组织细胞分裂并导致细胞死亡，具有抗肿瘤活性。

5'-chloro-5'-Deoxyadenosine (hydrate) is a nucleoside analog used as a substrate in polyketide biosynthesis. S-(5'-adenosyl)-L-methionine can be converted to 5'-chloro-5'-deoxyadenosine in a reaction catalyzed by a SAM-dependent chlorinase. Through a 7-step route, 5'-chloro-5'-deoxyadenosine can be converted to chloroethylmalonyl-CoA, which has been shown to be involved in the biosynthesis of the anticancer agent salinosporamide A in the marine bacterium S. tropica.