149
15
1
35
Cat. No. | Product Name | ||
---|---|---|---|
L9000 | 细胞凋亡化合物库 | 1760 compounds | |
1760 种与凋亡相关的生物活性小分子化合物的特有集合,多用于研究肿瘤发生发展机制和抗癌药物筛选等。可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T23760 |
AT-IAP
|
||
AT-IAP is an effective dual antagonist of XIAP and cIAP1. | |||
T5400 |
Q203
IAP6,Telacebec |
Antibacterial; Antibiotic | Microbiology/Virology |
Q203 (Telacebec)是一种中氮杂吡啶酰胺。 在培养基中抑制结核分枝杆菌H37Rv 活性的MIC50值为2.7 nM。 | |||
TP2292 |
survivin (baculoviral IAP repeat-containing protein 5) (21-28)
|
Others | Others |
Survivin (baculoviral inhibitor of apoptosis IAP repeat-containing protein-5) is a member of the IAP gene family, which has been implicated in both inhibitions of apoptosis and mitosis regulation1. Survivin is one of the most uniformly up-regulated genes | |||
T18612 |
Bestatin-amido-Me
PROTAC IAP binding moiety 1 |
Others | Others |
Bestatin-amido-Me, a derivative of Bestatin, acts as an IAP ligand and interacts with ABL inhibitor through a linker to produce SNIPER[1]. | |||
T18613 |
MV-1-NH-Me
PROTAC IAP binding moiety 2 |
Others | Others |
MV-1-NH-Me, an MV-1-derived IAP ligand, connects to an ABL inhibitor through a linker, resulting in the formation of SNIPER[1]. | |||
T74847 | PROTAC pan-IAP degrader-1 | ||
PROTACpan-IAP degrader-1 (Compound 9) 是一种 pan-IAPPROTAC 降解剂。PROTACpan-IAP degrader-1 在 MM.1S 细胞中降解 XIAP、cIAP1 和 cIAP2 的 DC50分别为 0.7、2.4 和 6.2 nM。 | |||
T12932L |
SM-164
|
Apoptosis; IAP | Apoptosis |
SM-164 是细胞渗透性 Smac 类似物,与含有 BIR2 和 BIR3 结构域的 XIAP 蛋白结合,IC50值为 1.39 nM,它用作XIAP 的强效拮抗剂。 | |||
T2080 |
LCL161
|
IAP | Apoptosis |
LCL161 是一种 SMAC 模拟物,可有效结合并抑制多种 IAP。它抑制 HEK293 细胞中 XIAP 和 MDA-MB-231细胞中 cIAP1的 IC50分别为 35 和 0.4 nM。 | |||
T6428 |
BV6
|
IAP | Apoptosis |
BV6 是 c-IAP1 和 XIAP 的拮抗剂,它们是凋亡抑制剂 (IAP) 家族的成员。 | |||
TQ0029 |
ASTX660
|
IAP | Apoptosis |
ASTX660 是一种口服生物可利用的 cIAP 和 XIAP 双重拮抗剂。 | |||
T6299 |
GDC-0152
GDC0152 |
IAP | Apoptosis |
GDC-0152 是一种 IAP 抑制剂,可以与 XIAP、cIAP1和cIAP2的 BIR3 结合域,以及ML-IAP 的 BIR 结合域结合,Ki 值分别为 28 nM、17 nM、43 nM 和 14 nM。 | |||
T16163 |
MV1
|
Apoptosis | Apoptosis |
MV1 是一种 IAP 拮抗剂。 当与 HaloTag 配体结合时,它会导致 HaloTag 融合蛋白的蛋白质敲低。 | |||
T6007 |
Birinapant
TL32711,比瑞那帕 |
Apoptosis; IAP; HIV Protease | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Birinapant (TL32711) 是一种二价 Smac 模拟物,是 XIAP 和 cIAP1的强效拮抗剂,Kd 值分别为 45 nM 和小于 1 nM。它靶向与 TRAF2 相关的 cIAP,并消除 TNF 诱导的 NF-κB 活化。 | |||
T3653 |
MX69
|
Mdm2; E1/E2/E3 Enzyme; IAP | Apoptosis; Ubiquitination |
MX69 是用于抗癌研究的一种MDM2/XIAP 抑制剂。 | |||
T6763 |
Xevinapant
ARRY-334543,SM-406,AT406,Debio-1143 |
IAP | Apoptosis |
Xevinapant (Debio-1143) 是一种有效的 Smac 模拟物和 IAP 的拮抗剂,能够抑制 XIAP,cIAP1 和 cIAP2 蛋白,Ki 值分别为 66.4,1.9 和 5.1 nM。 | |||
T14378 |
AZD5582
|
Apoptosis; IAP | Apoptosis |
AZD5582 是一种 IAP 拮抗剂,可诱导凋亡,可与 cIAP1、cIAP2 和 XIAP 的 BIR3 结构域结合,IC50值分别为 15、21和15 nM。 | |||
T3299 |
Xevinapant hydrochloride
AT-406 HCl,SM-406 |
Apoptosis; IAP | Apoptosis |
Xevinapant hydrochloride (AT-406 HCl) 是口服生物可利用的 Smac 模拟物,也是细胞凋亡蛋白抑制剂的拮抗剂。它在无细胞功能测定中有效拮抗 XIAP BIR3 蛋白,诱导细胞 cIAP1 蛋白的快速降解,并抑制各种人类癌细胞系中的癌细胞生长。它在诱导异种移植肿瘤细胞凋亡方面非常有效。 | |||
T17870 |
cIAP1 ligand 1
E3 ligase Ligand 12 |
Others | Others |
cIAP1 ligand 1 (E3 ligase Ligand 12) 是基于 LCL161 衍生物的细胞凋亡蛋白配体,可募集 IAP 泛素连接酶以降解靶蛋白,可用于和雄激素受体配体偶联开发蛋白降解剂,可用于研究前列腺癌。 | |||
T9519 |
Eliapixant
BAY 1817080 |
P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
Eliapixant (BAY 1817080) 是一种选择性的P2X3受体拮抗剂,IC50值为 8 nM,可用于难治性慢性咳嗽的研究。 | |||
T12405 |
Pentiapine
喷硫平,CGS 10746 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Pentiapine (CGS 10746) 是一种新型的多巴胺释放抑制剂。 | |||
T13154 |
Tiapamil hydrochloride
Ro 11-1781 hydrochloride,ORE 5002 hydrochloride |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Tiapamil hydrochloride (Ro 11-1781 hydrochloride) 是一种钙通道阻滞剂,具有抗高血压活性,可用于研究心绞痛和心血管疾病。 | |||
T36949 |
Niaprazine
|
5-HT Receptor; Adrenergic Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Niaprazine 是有效的组胺 H1 受体拮抗剂,具有抗组胺和抗血清素活性。Niaprazine 在睡眠障碍方面有研究的价值。 | |||
T6411 |
Biapenem
CLI 86815,比阿培南,Biapenern,Omegacin,L 627,LJC 10627 |
Antibacterial; Antibiotic | Microbiology/Virology |
Biapenem (CLI 86815) 是不经肠道的广谱碳青霉烯抗生素。 | |||
T16731 |
Rentiapril racemate
(Rac)-SA-446,SA-446 racemate,(Rac)-Rentiapril |
Angiotensin-converting Enzyme (ACE) | Metabolism |
Rentiapril racemate (SA-446 racemate) 是 Rentiapril 的外消旋体。Rentiapril racemate 具有抗炎活性,可用于研究青光眼。 | |||
T11506 |
Guaiapate
Mg 5454,Klamar |
Others | Others |
Guaiapate 具有止咳镇静作用。 | |||
T23900 |
Clothiapine
LW 2159,HF2159,氯噻平,HF-2159,HF 2159,S-805C |
||
Clothiapine is an atypical antipsychotic of the dibenzothiazepine chemical class. | |||
T6241 |
Quetiapine hemifumarate
Quetiapine Fumarate,ICI-204636,富马酸喹硫平 |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Quetiapine hemifumarate (ICI-204636) 是5-HT 受体激动剂和多巴胺受体拮抗剂,对人5-HT1A 和人D2的pEC50值分别为 4.77 和 6.33,具有抗抑郁和抗焦虑作用。 | |||
T0162 |
Quetiapine
ICI204636,Quetiapin,喹硫平 |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; AChR; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Quetiapine (ICI204636) 是5-HT 受体激动剂和多巴胺受体拮抗剂,对人5-HT1A 的 pEC50值为 4.77,对人 D2的 pIC50值为 6.33。它用于治疗精神分裂症,以及治疗与 I 型双相情感障碍相关的急性躁狂发作。它对人 D2、HT1、5-HT2A、5-HT2C 受体具有中高等亲和力,pKi 值为 7.25、5.74、7.54和5.55。 | |||
T4561 |
Tiaprofenic acid
Tiaprofensaeure,噻洛芬酸,Acido tiaprofenico,Surgam |
Others; COX | Immunology/Inflammation; Neuroscience; Others |
Tiaprofenic acid (Acido tiaprofenico) 是可口服的非甾体抗炎药,通过抑制环氧化酶抑制前列腺素合成,可用于风湿性疾病的研究。 | |||
T1292 |
Tiapride hydrochloride
|
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Tiapride 是一种大脑中 D2/3 多巴胺受体的选择性阻滞剂。 它用于治疗各种精神和神经系统疾病,包括运动障碍、酒精戒断综合征、精神病的阴性症状以及老年人的攻击和激动。 | |||
T17894 |
cIAP1 Ligand-Linker Conjugates 3
E3 ligase Ligand-Linker Conjugates 40 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 3 are chemical compounds comprising an IAP ligand designed specifically for the E3 ubiquitin ligase and a PROTAC linker. These conjugates, denoted as cIAP1 Ligand-Linker Conjugates 3, find utility in the design of SNIPERs, short for Specific and Non-genetic IAP-dependent Protein Erasers [1]. | |||
T17888 |
cIAP1 Ligand-Linker Conjugates 6 hydrochloride
E3 ligase Ligand-Linker Conjugates 35 hydrochloride |
Others | Others |
cIAP1 Ligand-Linker Conjugates 6 hydrochloride is a compound that combines an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. It is utilized for the purpose of designing SNIPERs[1]. | |||
T17891 |
cIAP1 Ligand-Linker Conjugates 2
E3 ligase Ligand-Linker Conjugates 37 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 2 is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker. This compound is particularly useful in the design of SNIPERs [1]. | |||
T17901 |
cIAP1 Ligand-Linker Conjugates 10
E3 ligase Ligand-Linker Conjugates 47 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 10 comprise of an IAP ligand and a PROTAC linker, which facilitates the design of SNIPERs. These conjugates incorporate an IAP ligand that interacts with the E3 ubiquitin ligase, and a PROTAC linker. SNIPERs can be developed using cIAP1 Ligand-Linker Conjugates 10. | |||
T17889 |
cIAP1 Ligand-Linker Conjugates 14
E3 ligase Ligand-Linker Conjugates 36 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 14 consist of an IAP ligand that targets the E3 ubiquitin ligase and a PROTAC linker. These conjugates, known as cIAP1 Ligand-Linker Conjugates 14, are used in the development of SNIPERs[1]. | |||
T17869 |
cIAP1 ligand 2
E3 ligase Ligand 11 |
Others | Others |
cIAP1 ligand 2, a derivative of LCL161, is an IAP ligand that can be connected to the ABL ligand for protein via a linker, resulting in the formation of SNIPER. | |||
T17898 |
cIAP1 Ligand-Linker Conjugates 7
E3 ligase Ligand-Linker Conjugates 44 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 7 is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker. It is utilized in the design of SNIPERs[1]. | |||
T17899 |
cIAP1 Ligand-Linker Conjugates 9
E3 ligase Ligand-Linker Conjugates 45 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 9 feature an IAP ligand specifically targeting the E3 ubiquitin ligase, along with a PROTAC linker. It is valuable tools for developing SNIPERs[1]. | |||
T17897 |
cIAP1 Ligand-Linker Conjugates 13
E3 ligase Ligand-Linker Conjugates 43 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 13, containing an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker, are utilized in the development of SNIPERs[1]. | |||
T17896 |
cIAP1 Ligand-Linker Conjugates 4
E3 ligase Ligand-Linker Conjugates 42 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 4 is a chemical compound that comprises an IAP ligand specifically designed for the E3 ubiquitin ligase and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 4, has the potential to be utilized in the development of SNIPERs[1]. | |||
T17886 |
cIAP1 Ligand-Linker Conjugates 15 hydrochloride
E3 ligase Ligand-Linker Conjugates 34 hydrochloride |
Others | Others |
cIAP1 Ligand-Linker Conjugates 15 hydrochloride is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is useful in the development of SNIPERs[1]. | |||
T17900 |
cIAP1 Ligand-Linker Conjugates 8
E3 ligase Ligand-Linker Conjugates 46 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 8 comprises an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is specifically utilized for the purpose of SNIPER design[1]. | |||
T17893 |
cIAP1 Ligand-Linker Conjugates 5
E3 ligase Ligand-Linker Conjugates 39 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 5 is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 5, is specifically designed for the development of SNIPERs[1]. | |||
T17885 |
cIAP1 Ligand-Linker Conjugates 11
E3 ligase Ligand-Linker Conjugates 33 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 11 is a chemical compound that combines an IAP ligand specifically designed for the E3 ubiquitin ligase with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 11, is useful in the development of SNIPERs[1], allowing for the targeted degradation of proteins. | |||
T17895 |
cIAP1 Ligand-Linker Conjugates 1
E3 ligase Ligand-Linker Conjugates 41 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 1 is composed of an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 1, is particularly useful in the development of SNIPERs[1]. | |||
T17890 |
cIAP1 Ligand-Linker Conjugates 2 Hydrochloride
E3 ligase Ligand-Linker Conjugates 37 Hydrochloride,cIAP1 Ligand-Linker Conjugates 2 Hydrochloride (1312302-14-9 free base) |
Others | Others |
cIAP1 Ligand-Linker Conjugates 2 Hydrochloride is a chemical compound that combines an IAP ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. It is utilized in the creation of SNIPERs[1]. | |||
T17884 |
cIAP1 Ligand-Linker Conjugates 11 Hydrochloride
E3 ligase Ligand-Linker Conjugates 33 Hydrochloride |
Others | Others |
cIAP1 Ligand-Linker Conjugates 11 Hydrochloride is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, along with a PROTAC linker. It is primarily utilized in the development of SNIPERs, a molecular tool for targeted protein degradation[1]. | |||
T17892 |
cIAP1 Ligand-Linker Conjugates 12
E3 ligase Ligand-Linker Conjugates 38 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 12 is a chemical compound that combines an IAP ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 12, is valuable for creating SNIPERs[1]. | |||
T17887 |
cIAP1 Ligand-Linker Conjugates 15
E3 ligase Ligand-Linker Conjugates 34 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 15 consists of an IAP ligand that targets the E3 ubiquitin ligase, along with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 15, is suitable for the development of SNIPERs[1]. | |||
T79483 | MDM2/XIAP-IN-3 | ||
MDM2/XIAP-IN-3(化合物 3e)为MDM2/XIAP双重抑制剂,能够下调MDM2与XIAP蛋白水平,提升p53表达,进而抑制癌细胞增殖并诱导细胞凋亡。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2091 |
Polygalacin D
|
Apoptosis; IAP | Apoptosis |
Polygalacin D 是从桔梗中分离的一种天然产物,具有抗癌和抗增殖特性。它通过 PI3K/Akt 途径诱导凋亡。它抑制 IAP 蛋白家族的表达,并通过抑制 GSK3β,Akt 的磷酸化和 PI3K 的表达来阻断 PI3K/Akt 途径。 | |||
T8213 |
Isolinderalactone
|
NOS; STAT | Immunology/Inflammation; JAK/STAT signaling; Stem Cells |
Isolinderalactone 具有抗炎和抗癌能力,具有中等的 iNOS 抑制活性,IC50 值为 0.30 uM。 | |||
T6485 |
Embelin
NSC 91874,恩贝酸,恩贝酸/恩贝灵,Emberine,Embelic acid |
Apoptosis; NF-κB; Lipoxygenase; IAP; Prostaglandin Receptor; Autophagy | Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; NF-κB |
Embelin (Embelic acid) 是从日本 Ardisia 草药中分离出来的一种非肽类细胞渗透性XIAP 抑制剂,诱导口腔鳞癌细胞自噬和凋亡。它阻断 NF-kappaB 信号通路,从而抑制 NF-kappaB 调节的抗凋亡和转移基因产物。在高水平 XIAP 的前列腺癌细胞中抑制细胞生长,诱导凋亡,并激活 caspase-9。 | |||
T4292 |
Thiaproline
L-Thioproline,L-Thiaproline,L-硫代脯氨酸 |
Others | Others |
Thiaproline (L-Thiaproline) 已用于肽偶联反应。 | |||
T38250 | L-Sepiapterin | ||
L-Sepiapterin, also known as Sepiapterin, is a precursor compound crucial for the production of tetrahydrobiopterin (BH4), which serves as a coenzyme for endothelial nitric oxide synthase (eNOS). This compound demonstrates its efficacy by improving endothelial dysfunction in small mesenteric arteries from db/db mice and promoting angiogenesis. Moreover, L-Sepiapterin exerts inhibitory effects on cellular proliferation and migration in ovarian cancer cells through the down-regulation of p70S6K-de... | |||
T75650 | Rivulariapeptolides 1121 | ||
Rivulariapeptolides 1121,作为一种高效的选择性丝氨酸蛋白酶抑制剂,对胰凝蛋白酶、弹性蛋白酶和蛋白酶K展示出了显著的抑制活性,其IC50值分别为35.52 nM、13.24 nM和48.05 nM。 | |||
T75649 | Rivulariapeptolides 1185 | ||
Rivulariapeptolides 1185 是一种高效的选择性丝氨酸蛋白酶抑制剂,其对胰凝蛋白酶、弹性蛋白酶和蛋白酶 K 的 IC50分别为 13.17 nM、23.59 nM 和 55.26 nM。 | |||
T75648 | Rivulariapeptolides 1155 | ||
Rivulariapeptolides 1155 是一种有效的丝氨酸蛋白酶 (serine protease) 抑制剂,对糜蛋白酶、弹性蛋白酶、蛋白蛋白酶 K 的 IC50分别为 41.84、4.94、56.54 nM。 | |||
TN1241 |
3,8''-Biapigenin
3,8'-Biapigenin,3,8″-双芹菜素 |
ROS | Immunology/Inflammation |
3, 8''-Biapigenin can modulate intracellular ROS production. | |||
TN5496 |
2'',3''-Dihydro-3',3'''-biapigenin
2,3-Dihydro-3',3'''-biapigenin |
||
2'',3''-Dihydro-3',3'''-biapigenin 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5496,CAS号为 151455-25-3。 | |||
TN5500 | 3',3'''-Biapigenin | ||
3',3'''-Biapigenin 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5500,CAS号为 151455-26-4。 | |||
TN6500 |
Microgrewiapine A
|
||
Microgrewiapine A is a selective cytotoxic agent for colon cancer cells over normal colon cells and to exhibit nicotinic receptor antagonistic activity for both the hα3β4 and hα4β2 receptor subtypes. | |||
T75651 | Rivulariapeptolides 988 | ||
Rivulariapeptolides 988作为一种高效选择性丝氨酸蛋白酶抑制剂,对胰凝蛋白酶、弹性蛋白酶和蛋白酶K的IC50分别为95.46 nM、15.29 nM和85.50 nM。 | |||
TN4598 |
Myrciaphenone A
|
Others | Others |
Myrciaphenone A is a natural product from Limoniastrum feei (Girard) Batt. | |||
TN5678 |
Salviaplebeiaside
|
||
Salviaplebeiaside is a natural product from Vitex negundo var. cannabifolia. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02650 |
Alkaline phosphatase Protein, Human, Recombinant (His)
IAP,alkaline phosphatase, intestinal |
Human | HEK293 |
ALPI encodes for intestinal phosphatase alkaline, a brush border metalloenzyme that hydrolyses phosphate from the lipid A moiety of lipopolysaccharides and thereby drastically reduces Toll-like receptor 4 agonist activity. ALPI mutations impaired either stability or catalytic activity of ALPI and rendered it unable to detoxify lipopolysaccharide-dependent signalling. ALPI mutations should be included in screening for monogenic causes of inflammatory bowel diseases and lay the groundwork for ALPI... | |||
TMPY-04935 |
CD47 Protein, Human, Recombinant (aa 1-139, His)
MER6,CD47 molecule,IAP,OA3 |
Human | HEK293 |
CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the b... | |||
TMPY-05191 |
CD47 Protein, Human, Recombinant, Biotinylated
CD47 molecule,MER6,OA3,IAP |
Human | HEK293 |
CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the b... | |||
TMPY-04683 |
CD47 Protein, Human, Recombinant
MER6,CD47 molecule,OA3,IAP |
Human | HEK293 |
CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the b... | |||
TMPY-00570 |
Alkaline Phosphatase/PLAP Protein, Human, Recombinant (His)
ALPI,PALP,PLAP,PLAP-1,alkaline phosphatase, placental,IA... |
Human | Yeast |
Most importantly, placental alkaline phosphatase (ALPP), an ectoenzyme that locates on cell surface with catalytic domains outside the plasma membrane and is overexpressed on many cancer cells, dephosphorylate the d-tyrosine phosphates on the surface of the magnetic nanoparticle and enable the magnetic nanoparticles to adhere selectively to the cancer cells, such as HeLa cells. Placental alkaline phosphatase (PLAP), encoded by the ALPP gene, is produced by the fetal side of the placenta. | |||
TMPY-04810 |
CD47 Protein, Mouse, Recombinant (His)
AA407862,CD47 molecule,AW108519,9130415E20Rik,AI848868,I... |
Mouse | HEK293 |
CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the b... | |||
TMPJ-00211 |
CD47 Protein, Human, Recombinant (His)
MER6,Integrin-Associated Protein,Leukocyte Surface Antigen C... |
Human | Human Cells |
CD47 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-45 KDa and the accession number is Q08722. | |||
TMPY-04118 |
Livin/BIRC7 Protein, Human, Recombinant (His)
MLIAP,baculoviral IAP repeat containing 7,... |
Human | E. coli |
BIRC7, a new member of inhibitor of the apoptosis protein family, is expressed in fetal tissues and most solid tumors in humans. BIRC7/livin expression is a novel prognostic marker in adult acute leukemia. Livin/BIRC7 is a member of the inhibitors of apoptosis proteins family, which are involved in tumor development through the inhibition of caspases. Livin/BIRC7 is specifically over-expressed in ACC, suggesting that it might be involved in adrenocortical tumorigenesis and represent a new molecu... | |||
TMPY-02713 |
Alkaline phosphatase Protein, Human, Recombinant (hFc)
alkaline phosphatase, intestinal,IAP |
Human | HEK293 |
ALPI encodes for intestinal phosphatase alkaline, a brush border metalloenzyme that hydrolyses phosphate from the lipid A moiety of lipopolysaccharides and thereby drastically reduces Toll-like receptor 4 agonist activity. ALPI mutations impaired either stability or catalytic activity of ALPI and rendered it unable to detoxify lipopolysaccharide-dependent signalling. ALPI mutations should be included in screening for monogenic causes of inflammatory bowel diseases and lay the groundwork for ALPI... | |||
TMPY-03883 |
CD47 Protein, Human, Recombinant (hFc)
OA3,CD47 molecule,IAP,MER6 |
Human | HEK293 |
CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the b... | |||
TMPH-03320 |
IAP-1 Protein, Rat, Recombinant (His)
|
Rat | HEK293 |
IAP-1 Protein, Rat, Recombinant (His) is expressed in HEK293. | |||
TMPY-00924 |
SMAC Protein, Human, Recombinant (His)
DFNA64,diablo, IAP-binding mitochondrial protein,SM... |
Human | E. coli |
Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric point, pI (Diablo) is a proapoptogenic mitochondrial protein that is released to the cytosol in response to diverse apoptotic stimuli, including commonly used chemotherapeutic drugs. The current knowlege about structure and function of Smac/Diablo during programmed cell death, bot... | |||
TMPY-06367 |
CD47 Protein, Human, Recombinant (aa 19-139, His)
OA3,CD47 molecule,MER6,IAP |
Human | HEK293 |
CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the b... | |||
TMPY-03672 |
Survivin Protein, Human, Recombinant
BIRC5,IAP4,API4,baculoviral IAP repeat con... |
Human | E. coli |
BIRC5, also known as Survivin and EPR-1, is a member of theIAP family. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but BIRC5 has only a single BIR domain. It is expressed cell cycle-dependently and highly expressed at mitosis. As a multitasking protein, BIRC5 has dual roles in promoting cell proliferation and preventing apoptosis. Survivin is a component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation... | |||
TMPY-06328 |
CD47 Protein, Mouse, Recombinant (His & Avi), Biotinylated
B430305P08Rik,AA407862,IAP,Itgp,CD47 molecule,AI848... |
Mouse | HEK293 |
CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the b... | |||
TMPK-00644 |
CD47 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)
CD47,OA3,IAP,CD47 molecule,CD47 glycoprotein,MER6 |
Cynomolgus,Rhesus macaque | HEK293 |
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα).CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers. | |||
TMPY-05378 |
CD47 Protein, Mouse, Recombinant (hFc)
9130415E20Rik,AA407862,B430305P08Rik,Itgp,CD47 molecule,AI84... |
Mouse | HEK293 |
CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the b... | |||
TMPY-04992 |
CD47 Protein, Mouse, Recombinant (rFc)
9130415E20Rik,AI848868,IAP,AA407862,AW108519,B43030... |
Mouse | HEK293 |
CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the b... | |||
TMPY-05467 |
CD47 Protein, Mouse, Recombinant
B430305P08Rik,AA407862,IAP,Itgp,9130415E20Rik,CD47 ... |
Mouse | HEK293 |
CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the b... | |||
TMPY-01176 |
cIAP1 Protein, Human, Recombinant (Avi)
Hiap-2,API1,HIAP2,RNF48,baculoviral IA... |
Human | E. coli |
The cellular inhibitor of apoptosis protein-1 (cIAP1) is a member of the Inhibitor of Apoptosis family proteins are (IAP) whose members are characterized by a novel domain of about 70 amino acids termed baculoviral IAP repeats (BIRs). The BIR domains of cIAP1 and cIAP2 bind to caspases, the key effector proteases of apoptosis. The IAP protein family which can enhance cell survival are crucial regulators of programmed cell death. Both cIAP1 and cIAP2 are the E3 ubiquitin protein isopeptide ligase... | |||
TMPK-00684 |
Alkaline phosphatase (Intestinal type) /ALPI Protein, Mouse, Recombinant (His)
IAP,TNSALP,APTNAP,FLJ40094,AP-TNAP,MGC161443,TNAP,A... |
Mouse | HEK293 |
Alkaline phosphatase can be considered "our favorite enzyme" for reasons apparent to those who diagnose and treat metabolic bone diseases or who study skeletal biology. Few might know, however, that alkaline phosphatase likely represents the most frequently assayed enzyme in all of medicine. Elevated activity in the circulation is universally recognized as a marker for skeletal or hepatobiliary disease. | |||
TMPY-02922 |
XIAP Protein, Human, Recombinant (His)
hIAP-3,API3,XLP2,ILP1,MIHA,X-linked inhibitor of ap... |
Human | E. coli |
E3 ubiquitin-protein ligase XIAP / BIRC4, also known as an inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, and IAP-like protein, is a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. XIAP / BIRC4 functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced ... | |||
TMPK-00796 |
Alkaline phosphatase (Intestinal type) /ALPI Protein, Human, Recombinant (His & Flag)
FLJ40094,ALPI,APTNAP,EC 3.1.3.1,AP-TNAP,IAP,TNAP,HO... |
Human | HEK293 |
Alkaline phosphatase can be considered "our favorite enzyme" for reasons apparent to those who diagnose and treat metabolic bone diseases or who study skeletal biology. Few might know, however, that alkaline phosphatase likely represents the most frequently assayed enzyme in all of medicine. Elevated activity in the circulation is universally recognized as a marker for skeletal or hepatobiliary disease. | |||
TMPH-02533 |
BIRC5 Protein, Mouse, Recombinant (His)
BIRC5,Baculoviral IAP repeat-containing protein 5,A... |
Mouse | Yeast |
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by ass... | |||
TMPH-02532 |
BIRC5 Protein, Mouse, Recombinant (E. coli, His)
Apoptosis inhibitor 4,Apoptosis inhibitor survivin,Baculovir... |
Mouse | E. coli |
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by ass... | |||
TMPY-01216 |
XIAP Protein, Human, Recombinant (Avi)
hIAP-3,IAP-3,MIHA,ILP1,BIRC4,hIAP... |
Human | E. coli |
E3 ubiquitin-protein ligase XIAP / BIRC4, also known as an inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, and IAP-like protein, is a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. XIAP / BIRC4 functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced ... | |||
TMPJ-00212 |
CD47 Protein, Human, Recombinant (mFc)
CD47,IAP,Integrin-associated protein,Antigenic surf... |
Human | Human Cells |
CD47(Integrin-Associated Protein,IAP) is a 40 ‑ 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 binds to SIRP family members on macrophages, neutrophils, and T cells. CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the C-terminal cell-binding domain of thrombospondin, and it may play a role in membrane transport and sig... | |||
TMPJ-00614 |
CD47 Protein, Rhesus macaque, Recombinant (His & Flag)
MER6,Integrin-Associated Protein,IAP,Leukocyte Surf... |
Rhesus Macaque | Human Cells |
CD47, also known as Integrin‑Associated Protein (IAP) and OA3, is a glycosylated atypical member of the immunoglobulin superfamily. Mouse CD47 is an integral membrane protein that consists of a extracellular domain (ECD) with a single Ig‑like domain, five membrane-spanning regions with short intervening loops, and C‑terminal cytoplasmic tail. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It plays an important r... | |||
TMPH-00992 |
BIRC5 Protein, Human, Recombinant (His & SUMO)
API4,Apoptosis inhibitor survivin,BIRC5,IAP4,Baculo... |
Human | E. coli |
BIRC5 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPJ-00613 |
CD47 Protein, Rhesus macaque, Recombinant (hFc)
Protein MER6,Integrin-Associated Protein,MER6,IAP,C... |
Rhesus macaque | Human Cells |
CD47(Integrin-Associated Protein,IAP) is a 40 ‑ 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 binds to SIRP family members on macrophages, neutrophils, and T cells. CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the C-terminal cell-binding domain of thrombospondin, and it may play a role in membrane transport and sig... | |||
TMPJ-00209 |
CD47 Protein, Human, Recombinant (Avi & His), Biotinylated
Protein MER6,Integrin-Associated Protein,MER6,CD47,Leukocyte... |
Human | Human Cells |
CD47(Integrin-Associated Protein,IAP) is a 40 ‑ 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 binds to SIRP family members on macrophages, neutrophils, and T cells. CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the C-terminal cell-binding domain of thrombospondin, and it may play a role in membrane transport and sig... | |||
TMPJ-00208 |
CD47 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Protein MER6,MER6,IAP,CD47,Antigenic surface determ... |
Human | Human Cells |
CD47(Integrin-Associated Protein,IAP) is a 40 ‑ 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 binds to SIRP family members on macrophages, neutrophils, and T cells. CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the C-terminal cell-binding domain of thrombospondin, and it may play a role in membrane transport and sig... | |||
TMPH-01563 |
IAPP Protein, Human, Recombinant (His)
|
Human | Yeast |
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. | |||
TMPH-01562 |
IAPP Protein, Human, Recombinant (GST)
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Human | E. coli |
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. | |||
TMPY-00725 |
COMP Protein, Human, Recombinant (His)
THBS5,MED,EPD1,PSACH,cartilage oligomeric matrix protein,EDM... |
Human | HEK293 |
Cartilage Oligomeric Matrix Protein (COMP), also referred to as Thrombospondin-5, is a non-collagenous extracellular matrix (ECM) protein and belongs to the subgroup B of the thrombospondin protein family. This protein is expressed primarily in cartilage, ligament, and tendon, and binds to other ECM proteins such as collagen I, II and IX with high affinities depending on the divalent cations Zn2+ or Ni2+. COMP is a secreted glycoprotein that is important for growth plate organization and functio... |