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Anti-SMAC Antibody (4Z608)
还可以产品编号 TMAY-00648
别名 SMAC, diablo, IAP-binding mitochondrial protein, DFNA64
Anti-SMAC Antibody (4Z608) 是一种 Mouse 抗体，靶向 SMAC。Anti-SMAC Antibody (4Z608) 可用于 WB,ELISA。
Anti-SMAC Antibody (4Z608)
Anti-SMAC Antibody (4Z608)
还可以产品编号 TMAY-00648 别名 SMAC, diablo, IAP-binding mitochondrial protein, DFNA64
Anti-SMAC Antibody (4Z608) 是一种 Mouse 抗体，靶向 SMAC。Anti-SMAC Antibody (4Z608) 可用于 WB,ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,689 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-SMAC Antibody (4Z608) is a Mouse antibody targeting SMAC. Anti-SMAC Antibody (4Z608) can be used in WB,ELISA. |
| 别名 | SMAC, diablo, IAP-binding mitochondrial protein, DFNA64 |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 4Z608 |
| 交叉反应 | Human |
| 验证活性 | Anti-Diablo mouse monoclonal antibody at 1:500 dilution. -Lane A: HepG2 Whole Cell Lysate. -Lane B: A431 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:22 kDa. -Observed band size:20 kDa |
| 应用 | WB,ELISA |
| 推荐剂量 | WB: 1:500-1:2000; ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Diablo (rh Diablo; TMPY-00924; NP_063940.1; Ala 56-Asp 239). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric point, pI (Diablo) is a proapoptogenic mitochondrial protein that is released to the cytosol in response to diverse apoptotic stimuli, including commonly used chemotherapeutic drugs. The current knowlege about structure and function of Smac/Diablo during programmed cell death, both in mitochondrial and receptor pathways are presented. It has been shown that Diablo mainly interacts with IAPs in the cytochrome c/Apaf-1/caspase-9 pathway, and promotes apoptosis. Diablo is released from the mitochondria into the cytosol occurring downstream of cytochrome c release in response to apoptotic stimuli such as irradiation, DNA damage or cytotoxic drugs. In the cytosol, Smac/Diablo interacts and antagonizes inhibitors of apoptosis proteins (IAPs), thus allowing the activation of caspases and apoptosis. This activity has prompted the synthesis of peptidomimetics that could potentially be used in cancer therapy. The role of Smac/DIABLO in colorectal carcinogenesis is ill defined. Data continues to accumulate to suggest that decreased levels of Smac/DIABLO may be important in chemoradiation-resistance to apoptosis in advanced colon cancer. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human Diablo protein (TMPY-00924) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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