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Apolipoprotein A-I/APOA1 Protein, Mouse, Recombinant (hFc)

产品编号 TMPY-06955

别名: Alp-1, 1-Sep, Ltw-1, Lvtw-1, Apoa-1, 42248, apolipoprotein A-I, 42249, apoA-I, Brp-14, apo-AI, 2-Sep

Apolipoprotein A-I/APOA1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.68 kDa and the accession number is Q00623.

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Apolipoprotein A-I/APOA1 Protein, Mouse, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 4,460		5日内发货
1 mg	￥ 29,000		5日内发货

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生物活性	Testing in progress
产品描述	Apolipoprotein A-I/APOA1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.68 kDa and the accession number is Q00623.

种属	Mouse
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	Q00623
别名	Alp-1, 1-Sep, Ltw-1, Lvtw-1, Apoa-1, 42248, apolipoprotein A-I, 42249, apoA-I, Brp-14, apo-AI, 2-Sep
蛋白构建	The Mouse APOA1 (Q00623) (Asp25-Gln264) was expressed with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
分子量	54.68 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Apolipoprotein A1 (APOA1) is a member of the apolipoprotein family whose members are proteins bind with lipids and form lipoproteins to translate these oil-soluble lipids such as fat and cholesterol through lymphatic and circulatory system. APOA1 is the main component of high density lipoprotein (HDL) in plasma and is involved in the esterification of cholesterol as a cofactor of lecithin-cholesterol acyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters, and thus play a major role in cholesterol efflux from peripheral cells. As a major component of the HDL complex, APOA1 helps to clear cholesterol from arteries. APOA1 is also characterized as a prostacyclin stabilizing factor, and thus may have an anticlotting effect. Defects in encoding gene may result in HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Men carrying a mutation may develop premature coronary artery disease.

参考文献

1. Toptas B,et al.(2011) Comparison of lipid profiles with APOA1 MspI polymorphism in obese children with hyperlipidemia. In Vivo. 25(3): 425-30. 2. Haase CL,et al.(2011) Mutation in APOA1 predicts increased risk of ischaemic heart disease and total mortality without low HDL cholesterol levels. J Intern Med. 270(2): 136-46. 3. Wu Z,et al.(2011) The low resolution structure of ApoA1 in spherical high density lipoprotein revealed small angle neutron scattering. J Biol Chem. 286(14): 12495-508.

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Keywords

Apolipoprotein A-I/APOA1 Protein, Mouse, Recombinant (hFc) Alp-1 1-Sep Ltw-1 Lvtw-1 Apoa-1 42248 apolipoprotein A-I 42249 apoA-I Brp-14 apo-AI 2-Sep recombinant recombinant-proteins proteins protein

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