购物车
- 全部删除
您的购物车当前为空
Anti-SMAC Antibody (5G346)
还可以
产品编号 TMAY-00650
别名 SMAC, diablo, IAP-binding mitochondrial protein, DFNA64
Anti-SMAC Antibody (5G346) 是一种 Rabbit 抗体，靶向 SMAC。Anti-SMAC Antibody (5G346) 可用于 IP。
Anti-SMAC Antibody (5G346)
331 Anti-SMAC Antibody (5G346)
还可以产品编号 TMAY-00650 别名 SMAC, diablo, IAP-binding mitochondrial protein, DFNA64
Anti-SMAC Antibody (5G346) 是一种 Rabbit 抗体，靶向 SMAC。Anti-SMAC Antibody (5G346) 可用于 IP。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 2,289 | 5日内发货 |
大包装 & 定制
加入购物车
TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
联系我们获取更多批次信息
资源下载
产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-SMAC Antibody (5G346) is a Rabbit antibody targeting SMAC. Anti-SMAC Antibody (5G346) can be used in IP. |
| 别名 | SMAC, diablo, IAP-binding mitochondrial protein, DFNA64 |
| Ig Type | Rabbit IgG |
| 克隆号 | 5G346 |
| 交叉反应 | Human |
| 验证活性 | Diablo was immunoprecipitated using: -Lane A:0.5 mg 293T Whole Cell Lysate. -Lane B:0.5 mg MCF-7 Whole Cell Lysate. -Lane C:0.5 mg HepG2 Whole Cell Lysate. -2 µL anti-Diablo rabbit monoclonal antibody and 15 μl of 50 % Protein G agarose. -Primary antibody: -Anti-Diablo rabbit monoclonal antibody, at 1:330 dilution. -Secondary antibody: -Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution. -Developed using the odyssey technique. -Performed under reducing conditions. -Predicted band size: 19 kDa. -Observed band size: 19 kDa |
| 应用 | IP |
| 推荐剂量 | IP: 0.5-2 μL/mg of lysate |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human SMAC / Diablo (rh SMAC / Diablo; TMPY-00924; NP_063940.1; Ala56-Asp239). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric point, pI (Diablo) is a proapoptogenic mitochondrial protein that is released to the cytosol in response to diverse apoptotic stimuli, including commonly used chemotherapeutic drugs. The current knowlege about structure and function of Smac/Diablo during programmed cell death, both in mitochondrial and receptor pathways are presented. It has been shown that Diablo mainly interacts with IAPs in the cytochrome c/Apaf-1/caspase-9 pathway, and promotes apoptosis. Diablo is released from the mitochondria into the cytosol occurring downstream of cytochrome c release in response to apoptotic stimuli such as irradiation, DNA damage or cytotoxic drugs. In the cytosol, Smac/Diablo interacts and antagonizes inhibitors of apoptosis proteins (IAPs), thus allowing the activation of caspases and apoptosis. This activity has prompted the synthesis of peptidomimetics that could potentially be used in cancer therapy. The role of Smac/DIABLO in colorectal carcinogenesis is ill defined. Data continues to accumulate to suggest that decreased levels of Smac/DIABLO may be important in chemoradiation-resistance to apoptosis in advanced colon cancer. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human SMAC / Diablo Protein (TMPY-00924) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
SCI 文献
评论列表
预览
Related Tags: buy Anti-SMAC Antibody (5G346) | purchase Anti-SMAC Antibody (5G346) | Anti-SMAC Antibody (5G346) cost | order Anti-SMAC Antibody (5G346)
嗨！有任何问题？点我咨询
评论内容