| Cat. No. | Product Name | Target | Signaling Pathways |
|---|---|---|---|
| T10831 | Cl-amidine | Others | Others |
| Cl-amidine is an orally active inhibitor of peptidyl arginine deminase (PAD) (IC50s: 0.8 μM, 6.2 μM, and 5.9 μM for PAD1, PAD3, and PAD4). Cl-amidine induces apoptosis in cancer cells. | |||
| T10831L | Cl-amidine hydrochloride | PAD; Apoptosis | Apoptosis; Chromatin/Epigenetic |
| Cl-amidine hydrochloride 是一种口服有效的PAD 抑制剂，可阻断组蛋白 3 瓜氨酸化和中性粒细胞胞外陷阱的形成，并提高败血症小鼠的存活率。它可诱导癌细胞凋亡，还可诱导 miR-16 引起细胞周期阻滞。 | |||
| T10482 | BB-Cl-Amidine | PAD | Chromatin/Epigenetic |
| BB-Cl-Amidine 是一种肽基精氨酸脱胺酶抑制剂。 | |||
| T61155 | D-Cl-amidine hydrochloride | ||
| D-Cl-amidine hydrochloride is a potent and highly selective inhibitor of PAD1. It exhibits excellent tolerance and does not induce significant toxicity [1]. | |||
| T10932 | D-Cl-amidine | Others | Others |
| D-Cl-amidine is an effective and highly selective PAD1 inhibitor. D-Cl-amidine has a good correlation and no obvious toxicity. | |||
| T10831L2 | Cl-amidine TFA | Others | Others |
| Cl-amidine TFA is an orally active inhibitor of peptidyl arginine deminase (PAD) (IC50s: 0.8 μM, 6.2 μM, and 5.9 μM for PAD1, PAD3, and PAD4). Cl-amidine induces apoptosis in cancer cells. | |||
| T10482L |
BB-Cl-Amidine hydrochloride
BB-Cl-Amidine hydrochloride (1802637-39-3 free base) |
Others | Others |
| BB-Cl-Amidine hydrochloride 是一种肽基精氨酸脱胺酶(PAD)的抑制剂。 | |||
| T9828 | N-[1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]benzamide | PAD | Chromatin/Epigenetic |
| N-[1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]benzamide 是Cl-amidine (S 构型)的消旋形式。Cl-amidine 口服有效的 PAD 抑制剂。 | |||
| T36633 | BB-F-Yne | ||
| BB-F-Yne is a cell-permeable derivative of the protein arginine diminase (PAD) inhibitor BB-Cl-amidine that contains an alkyne moiety for use in click chemistry reactions. BB-F-Yne inhibits PAD1-4 with Kinact/KI values of 900, 1,200, 3,400, and 3,750 M-1min-1, respectively. It has been used for labeling PADs in cell-free and cell-based assays, followed by click reactions with azide-modified TAMRA or biotin reporters. | |||
| T36632 | BB-Cl-Yne | ||
| BB-Cl-Yne is a cell-permeable derivative of the protein arginine deiminase (PAD) inhibitor BB-Cl-amidine that contains an alkyne moiety for use in click chemistry reactions. BB-CL-Yne inhibits PAD1-4 with Kinact/KI values of 6,400, 3,600, 10,800, and 4,900 M-1min-1, respectively. It has been used for labeling PADs in cell-free and cell-based assays, followed by click reactions with azide-modified TAMRA or biotin reporters. | |||
| T35817 | Photoswitchable PAD Inhibitor (technical grade) | ||
| Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity.1 Without photoactivation, it is a weak inhibitor of PAD2 (IC50 = >100 μM) and is less potent than BB-Cl-amidine in inhibiting citrulline production in vitro (kinact/KIs = 2,300, 600, 1,000, and 10,510 M-1min-1 for PAD1-4, respectively) and does not inhibit histone H3 citrullination in HEK29... | |||
| T36107 |
YW3-56
YW3-56 |
||
| YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor, with an IC50 of 1-5 μM for PAD4. Compared with Cl-amidine, YW3-56 shows >60-fold increase in cell growth inhibition efficacy (IC50 about 2.5 μM) but only 5-fold increase in PAD4 inhibition (IC sub>50 about 1-5 μM). At 2-4 μM concentrations, YW3-56 displays mainly cytostatic effects by slowing cell division, whereas at higher concentrations, it exerts cytotoxic effects by altering cell morphology and killing cells[1]. [1]. Wang Y, et ... | |||
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