在免疫学中,Fc 受体是存在于某些细胞表面的一种蛋白质,包括 B 淋巴细胞、滤泡树突状细胞、自然杀伤细胞、巨噬细胞、中性粒细胞、嗜酸性粒细胞、嗜碱性粒细胞、人血小板和肥大细胞,它们有助于免疫系统的保护功能。Fc受体与附着在被感染细胞或入侵病原体上的抗体结合,它们的活性刺激吞噬细胞或细胞毒性细胞破坏微生物,或通过抗体介导的吞噬作用或抗体依赖的细胞介导的细胞毒性感染细胞。
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE), a potent anti-mitotic agent. FcRH5 FcRL5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 92.38 kDa and the accession number is AAK93971.
Mouse IgG2c is a subclass of mouse antibody IgG, it can bind FcγRIV with high affinity and the Fc loop residues of mouse IgG2c promote greater receptor-binding affinity than mouse IgG2b or human IgG1.
FCGR4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.4 kDa and the accession number is A0A0B4J1G0.