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CD16a Protein, Human, Recombinant (176 Phe, His)

CD16a Protein, Human, Recombinant (176 Phe, His)

产品编号 TMPY-02816
别名: IGFR3, CD16, FCR-10, FCRIIIA, CD16A, Fc γ RIIIa, Fc fragment of IgG, low affinity IIIa, receptor (CD16a), IMD20, FCGR3, FCRIII, Fc gamma RIIIa, FCG3, FCGRIII

CD16a Protein, Human, Recombinant (176 Phe, His) is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P08637-1.

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CD16a Protein, Human, Recombinant (176 Phe, His)
规格 价格/CNY 货期 数量
100 μg ¥ 3,820 5日内发货
1 mg ¥ 24,900 5日内发货
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产品目录号及名称: CD16a Protein, Human, Recombinant (176 Phe, His) (TMPY-02816)
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生物活性 Testing in progress
产品描述 CD16a Protein, Human, Recombinant (176 Phe, His) is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P08637-1.
种属 Human
表达系统 CHO Cells
标签 C-His
蛋白编号 P08637-1
别名 IGFR3, CD16, FCR-10, FCRIIIA, CD16A, Fc γ RIIIa, Fc fragment of IgG, low affinity IIIa, receptor (CD16a), IMD20, FCGR3, FCRIII, Fc gamma RIIIa, FCG3, FCGRIII
蛋白构建 extracellular domain (Met 1-Gln 208) of Human CD16a (P08637-1) precursor
蛋白纯度 ≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
分子量 23.3 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells. CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a / FCGR3A also has a broader function. CD16a / FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a / FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a / FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation.

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Keywords

CD16a Protein, Human, Recombinant (176 Phe, His) IMD 20 IGFR3 FCG 3 CD16 Fc fragment of IgG, low affinity IIIa, receptor FCR-10 FCGR-3 FCRIIIA FCGR 3 FCR 10 CD-16 CD16A Fc γ RIIIa IMD-20 Fc fragment of IgG, low affinity IIIa, receptor (CD16a) CD 16 Fc gamma RIIIa IMD20 FCGR3 FCRIII IGFR-3 IGFR 3 FCG-3 Fc gamma RIIIa FCR10 FCG3 FCGRIII CD16a recombinant recombinant-proteins proteins protein

 

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