首页 工具
登录
购物车
CD32A Protein, Human, Recombinant (R167, His)

CD32A Protein, Human, Recombinant (R167, His)

产品编号 TMPJ-00446
别名: FcRII-a, IGFR2, Low Affinity Immunoglobulin Gamma Fc Region Receptor II-a, Fc-Gamma RII-a, FCGR2A1, Fc-γ RII-a, FCGR2A, CDw32, FCG2, Fc-Gamma-RIIa, CD32, Low Affinity Immunoglobulin γ Fc Region Receptor II-a, IgG Fc receptor II-a, Fc-γ-RIIa

Receptors for the Fc region of IgG (FcγR) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Human FcγRs are divided into three classes designated FcγRI (CD64), FcγRII (CD32), and FcγRIII (CD16), which generate multiple isoforms, are recognized. The activating­ type receptor either has or associates non­covalently with an accessory subunit that has an immunoreceptor tyrosine­based activation motif (ITAM) in its cytoplasmic domain. FcγRI binds IgG with high affinity and functions during early immune responses, whereas FcγRII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. Three genes for human FcγRII (A, B, and C) and one for mouse (FcγRIIB), encoding type I transmembrane proteins with ITAM motifs (FcγRII A and C) or ITIM motifs (FcγRIIB) in their cytoplasmic domains, have been identified. Human CD32, also known as Low affinity immunoglobulin γ Fc region receptor II-a (IgG Fc receptor II-a), FcγRII A or FCGR2A Protein, is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. Associated with an ITAM-bearing adapter subunit, FcRγ, CD32a (FcγRII A) delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation, and cytokine production. The responses can be modulated by signals from the co-expressed inhibitory receptors such as Fcγ RII B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.

TargetMol的所有产品和服务仅用于科学研究,不能被用于人体,我们也不向个人提供产品和服务。
TargetMol
CD32A Protein, Human, Recombinant (R167, His)
规格 价格/CNY 货期 数量
10 μg ¥ 620 5日内发货
50 μg ¥ 1,730 5日内发货
500 μg ¥ 12,100 5日内发货
1 mg ¥ 17,400 5日内发货
磁珠产品首单3折起
夏季3重特惠
药物设计专题培训
产品目录号及名称: CD32A Protein, Human, Recombinant (R167, His) (TMPJ-00446)
点击图片重新获取验证码
更多批次查询请联系客服
生物活性
技术参数
产品性质
生物活性 Loaded Human CD32a-His on HIS1K Biosensor, can bind Anti-Human HER2 mAb with an affinity constant of 1.1 uM as determined in BLI assay. (Regularly tested)
产品描述 Receptors for the Fc region of IgG (FcγR) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Human FcγRs are divided into three classes designated FcγRI (CD64), FcγRII (CD32), and FcγRIII (CD16), which generate multiple isoforms, are recognized. The activating­ type receptor either has or associates non­covalently with an accessory subunit that has an immunoreceptor tyrosine­based activation motif (ITAM) in its cytoplasmic domain. FcγRI binds IgG with high affinity and functions during early immune responses, whereas FcγRII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. Three genes for human FcγRII (A, B, and C) and one for mouse (FcγRIIB), encoding type I transmembrane proteins with ITAM motifs (FcγRII A and C) or ITIM motifs (FcγRIIB) in their cytoplasmic domains, have been identified. Human CD32, also known as Low affinity immunoglobulin γ Fc region receptor II-a (IgG Fc receptor II-a), FcγRII A or FCGR2A Protein, is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. Associated with an ITAM-bearing adapter subunit, FcRγ, CD32a (FcγRII A) delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation, and cytokine production. The responses can be modulated by signals from the co-expressed inhibitory receptors such as Fcγ RII B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.
种属 Human
表达系统 HEK293 Cells
标签 C-6xHis
蛋白编号 AAA35827
别名 FcRII-a, IGFR2, Low Affinity Immunoglobulin Gamma Fc Region Receptor II-a, Fc-Gamma RII-a, FCGR2A1, Fc-γ RII-a, FCGR2A, CDw32, FCG2, Fc-Gamma-RIIa, CD32, Low Affinity Immunoglobulin γ Fc Region Receptor II-a, IgG Fc receptor II-a, Fc-γ-RIIa
氨基酸序列 Ala36-Ile218
蛋白构建 Ala36-Ile218. It is identical to FCGR2A131H/R in the reference.
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. Greater than 95% as determined by SEC-HPLC.
分子量 25-32 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Receptors for the Fc region of IgG (FcγR) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Human FcγRs are divided into three classes designated FcγRI (CD64), FcγRII (CD32), and FcγRIII (CD16), which generate multiple isoforms, are recognized. The activating­ type receptor either has or associates non­covalently with an accessory subunit that has an immunoreceptor tyrosine­based activation motif (ITAM) in its cytoplasmic domain. FcγRI binds IgG with high affinity and functions during early immune responses, whereas FcγRII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. Three genes for human FcγRII (A, B, and C) and one for mouse (FcγRIIB), encoding type I transmembrane proteins with ITAM motifs (FcγRII A and C) or ITIM motifs (FcγRIIB) in their cytoplasmic domains, have been identified. Human CD32, also known as Low affinity immunoglobulin γ Fc region receptor II-a (IgG Fc receptor II-a), FcγRII A or FCGR2A Protein, is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. Associated with an ITAM-bearing adapter subunit, FcRγ, CD32a (FcγRII A) delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation, and cytokine production. The responses can be modulated by signals from the co-expressed inhibitory receptors such as Fcγ RII B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.

TargetMol Protein Calculator计算器

复溶计算器
重组蛋白稀释计算器
比活力计算器
=
÷
X
=
X
(Unit/mg)
= 106 ÷
ng/mL

bottom

技术支持

您可能有的问题的答案可以在重组蛋白操作手册中找到

Keywords

CD32A Protein, Human, Recombinant (R167, His) FcRII-a IGFR2 Low Affinity Immunoglobulin Gamma Fc Region Receptor II-a Fc-Gamma RII-a FCGR2A1 Fc-γ RII-a IGFR 2 FCGR2A CDw32 FCG2 Fc-Gamma-RIIa CD32 Low Affinity Immunoglobulin γ Fc Region Receptor II-a CD 32 IgG Fc receptor II-a IGFR-2 Fc-γ-RIIa FCG 2 FCG-2 CD-32 recombinant recombinant-proteins proteins protein

 

陶术
生物
TargetMol®中国区唯一合作伙伴
点击进入陶术生物官网陶术生物
联系我们
400-820-0310

上海市静安区江场三路238号8楼