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Fc epsilon RI Protein, Human, Recombinant

产品编号 TMPY-05084

别名: alpha polypeptide, FcERI, α polypeptide, Fc fragment of IgE, high affinity I, receptor for, Fc ε RI, FCE1A

Fc epsilon RI Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 21 kDa and the accession number is P12319.

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Fc epsilon RI Protein, Human, Recombinant

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		现货
200 μg	￥ 6,750		5日内发货
500 μg	￥ 14,280		5日内发货

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生物活性	Testing in progress
产品描述	Fc epsilon RI Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 21 kDa and the accession number is P12319.

种属	Human
表达系统	HEK293 Cells
标签	Tag Free
蛋白编号	P12319
别名	alpha polypeptide, FcERI, α polypeptide, Fc fragment of IgE, high affinity I, receptor for, Fc ε RI, FCE1A
蛋白构建	Human FCER1A (NP_001992.1) (Met1-Gln205)
蛋白纯度	≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
分子量	21 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	FcERI, also known as FCER1A, is the alpha subunit of the immunoglobulin epsilon receptor (IgE receptor). IgE receptor is a high affinity IgE receptor which plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. IgE receptor is comprised of an alpha subunit(FcERI), a beta subunit, and two gamma subunits. FcERI is glycosylated and contains 2 Ig-like (immunoglobulin-like) domains.

参考文献

1. Shikanai T,et al.(2002) Sequence variants in the FcepsilonRI alpha chain gene. J Appl Physiol. 93(1):37-41. 2. Sada K,et al.(2002) Regulation of FcepsilonRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells. Blood. 100(6):2138-44. 3. Takahashi K,et al.(2003) Transcriptional regulation of the human high affinity IgE receptor alpha-chain gene. Mol Immunol. 38(16-18):1193-9.

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Keywords

Fc epsilon RI Protein, Human, Recombinant alpha polypeptide FcERI α polypeptide Fc fragment of IgE, high affinity I, receptor for Fc ε RI FCE1A a polypeptide recombinant recombinant-proteins proteins protein

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