Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target formonoclonal antibody therapy for malignancies.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 μg | ¥ 740 | 5日内发货 | ||
50 μg | ¥ 1,970 | 5日内发货 | ||
500 μg | ¥ 12,100 | 5日内发货 | ||
1 mg | ¥ 17,400 | 5日内发货 |
生物活性 | Loaded Mouse CD32-His on HIS1K Biosensor, can bind Anti-Human HER2 mAb with an affinity constant of 1.14 uM as determined in BLI assay. (Regularly tested) |
产品描述 | Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target formonoclonal antibody therapy for malignancies. |
种属 | Mouse |
表达系统 | Human Cells |
标签 | C-6His |
蛋白编号 | P08101 |
别名 | Fcgr2, Fcgr2b, Fc-γ-RIIB, Fc-γ RII, Low affinity immunoglobulin γ Fc region receptor II, Fc gamma receptor IIB, Low affinity immunoglobulin gamma Fc region receptor II, Fc γ receptor IIB, Ly-17, Fc-gamma RII, FcRII, IgG Fc receptor II beta, CD32, IgG Fc receptor II β, Lymphocyte antigen 17, Fc-gamma-RIIB |
氨基酸序列 | Thr30-Pro210 |
蛋白构建 | Recombinant Mouse Low Affinity Immunoglobulin Gamma Fc Region Receptor II is produced by our Mammalian expression system and the target gene encoding Thr30-Pro210 is expressed with a 6His tag at the C-terminus. |
蛋白纯度 | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 33 KDa, reducing conditions |
内毒素 | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
缓冲液 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
复溶方法 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
存储 |
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
运输方式 |
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
研究背景 | Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target formonoclonal antibody therapy for malignancies. |
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CD32B Protein, Mouse, Recombinant (His) Fcgr2 Fcgr2b CD 32 CD-32 Fc-γ-RIIB Fc-γ RII Low affinity immunoglobulin γ Fc region receptor II Fc gamma receptor IIB Low affinity immunoglobulin gamma Fc region receptor II Fc γ receptor IIB Ly-17 Fc-gamma RII FcRII IgG Fc receptor II beta CD32 IgG Fc receptor II β Lymphocyte antigen 17 Fc-gamma-RIIB recombinant recombinant-proteins proteins protein