ZBP1 Covalent PROTAC-2 (2a+aptamer) is a covalent PROTAC (proteolysis-targeting chimeric molecule) targeting the Z-DNA binding protein 1 (ZBP1). This compound consists of a DNA aptamer, which specifically binds to ZBP1, and an E3 enzyme recruiting unit. By integrating the high specificity of the DNA aptamer, the efficiency of covalent binding, and the degradation-inducing capability of PROTACs, ZBP1 Covalent PROTAC-2 represents a powerful tool for targeted protein degradation.