gpr120

GPR120 Agonist 2 是一种选择性 GPR120激动剂。

GPR120 Agonist 3 (GPR120-IN-1) 是一种有效的、选择性的 Gpr120激动剂，logEC50为 −7.62。

GPR120 Agonist 1 is a selective GPR120 agonist. In GPR120 transfected HEK293 cells, GPR120 Agonist 1 displays good EC50 of 42 nM and 77 nM for human and mouse GPR120 (the calcium flux assay), respectively.

TUG-891 是一种选择性的长链游离脂肪酸受体 4 (FFA4 GPR120) 的激动剂。

GSK137647A (GSK 137647) 是一种选择性FFA4激动剂，作用于人类和大小鼠FFA4的pEC50分别为6.3、6.1和6.2。

AH-7614 (AH 7614) 是一种选择性的游离脂肪酸受体 4(FFA4 GPR120) 拮抗剂，对人和大小鼠 FFA4 的pIC50值分别为 7.1、8.1 和 8.1。它能够阻断多不饱和 ω-6 脂肪酸亚油酸和 FFA4 激动剂的作用。

GPR120 modulator 1 is useful for modulating GPR120.

GPR120 Agonist 4 (例子1) 作为GPR120激动剂，展示了针对β-arrestin A和Calcium A的EC50值，分别为1 μM和0.35 μM。该化合物主要用于II型糖尿病的相关研究。

MEDICA16 是 GPR40 的特异性激动剂以及 GPR120 的部分激动剂。 MEDICA16 是一种 ATP-柠檬酸裂解酶抑制剂，可显着降低腓肠肌中的细胞内 TG 含量，同时增加胰岛素敏感性。

GW 9508 是一种选择性 G 蛋白偶联受体FFA1(GPR40) 和GPR120激动剂。它是一种葡萄糖敏感性胰岛素促分泌剂和 ATP 敏感性钾通道开放剂，具有抗炎和抗动脉粥样硬化活性。

Ginsenoside Rb2 (Ginsenoside C) 是人参提取物中的一种主要生物活性成分，具有抗病毒活性，可上调 GPR120 基因表达。

GPR120 modulator 2 is useful for modulating GPR120.

GPR120-IN-1 is a novel GPR120 inhibitor, showing ~90% inhibitory effects on cell growth with micromolar affinities against SW480.

(+ -)-Pinocembrin (NSC-43318) 是一种来自腋松的天然产物，它是一种 GPR120 配体，能促进 HaCaT 细胞系的伤口愈合。

NCG21 is a GPR120 agonist, which showed potent extracellular signal-regulated kinase (ERK) activation in a cloned GPR120 system. NCG21 potently activated ERK, intracellular calcium responses and GLP-1 secretion in murine enteroendocrine STC-1 cells that e

TUG-905 is an agonist for free fatty acid receptor 4 (FFA4 GPR120), and TUG-905 has the potential to treat agitation.

Selective medium-chain free fatty acid receptor GPR84 agonist (EC50 = 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 μM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK1/2 phosphorylation, receptor desensitization and internalization in vitro. Liu et al (2016) Design and synthesis of 2-alkylpyrimidine-4,6-diol and 6-alkylpyridine-2,4-diol as potent GPR84 agonists. ACS Med.Chem.Lett. 7 579 PMID:27326330 |Zhang et al (2016) Discovery and characterization of a novel small-molecule agonist for medium-chain free fatty acid receptor G protein-coupled receptor 84. J.Pharmacol.Exp.Ther. 357 337 PMID:26962172

Metabolex-36 is a selective GPR120 agonist

1,1'-(Azodicarbonyl)dipiperidine (ADDP) serves as a widely employed reagent in the Mitsunobu reaction, facilitating the condensation between an alcohol and an acidic compound. Moreover, ADDP has found application in synthesizing agonists for the G protein-coupled receptor 120 (GPR120) with potential antidiabetic effects as well as in the creation of triple agonists for peroxisome proliferator-activated receptor α (PPARα), PPARγ, and PPARδ.

GprA为新合成的GPR120 FFAR4激动剂,具有针对人类GPR120全长同工型的AC50值为203 nM.该化合物主要应用于非酒精性脂肪性肝病(NAFLD)的研究领域.

AMG 837 calcium hydrate 是口服有效的 GPR40 FFA1部分激动剂，抑制 [3H]AMG 837 与人类 FFA1受体的特异性结合，pIC50为 8.13。AMG 837 calcium hydrate 可增强啮齿动物的胰岛素分泌并降低葡萄糖水平。