TAT-D1 peptide acetate is an inhibitor of the dopamine D1-D2 receptor heterodimer. It disrupts the function of these receptor heterodimers, enhancing subchronic amphetamine-induced spontaneous activity and intensifying the expression of sensitization to amphetamine-induced activity. In rat models of depression and anxiety, TAT-D1 peptide acetate rapidly produces anxiolytic and antidepressant-like effects and suppresses c-fos expression in the nucleus accumbens. This compound is utilized in the research of psychostimulant addiction, depression, and anxiety disorders.