Sulfinalol shows direct vasodilator activity and antihypertensive activity [1]. Animal Model: Mongrel dogs weighing 8.7-21.2 kg were anesthetized with pentobarbital (30-35 mg/kg, i.v., followed by a continuous infusion of 4 mg/kg/h) [1] Dosage: 0-100 μg Administration: Intraarterial injection Result: Increased blood flow in the sympathetically denervated hindlimb of anesthetized dogs. Animal Model: Male spontaneously hypertensive rats (SHR) [1] Dosage: 2.5 mg/kg Administration: Oral administration Result: Reduced pressure of conscious spontaneously hypertensive rats.