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Sulfalene

Name: Sulfalene
Brand: TargetMol
SKU: T0026
Price: 108 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.52%

货号 T0026Cas号 152-47-6

别名 磺胺林, Sulfametopyrazine, Sulfalene(SMPZ), Sulfalen, SMP2, Butadiene sulfone, AS-18908, 3-Sulfolene

Sulfalene (SMP2) 是一种长效磺胺类抗生素，用于治疗慢性支气管炎、尿路感染和疟疾。

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Sulfalene

一键复制产品信息

很棒

纯度: 99.52%

货号 T0026 别名 磺胺林, Sulfametopyrazine, Sulfalene(SMPZ), Sulfalen, SMP2, Butadiene sulfone, AS-18908, 3-SulfoleneCas号 152-47-6

Sulfalene (SMP2) 是一种长效磺胺类抗生素，用于治疗慢性支气管炎、尿路感染和疟疾。

规格	价格	库存
25 mg	¥ 108	现货
50 mg	¥ 148	现货
100 mg	¥ 248	现货
500 mg	¥ 598	现货
1 g	¥ 882	现货
1 mL x 10 mM (in DMSO)	¥ 163	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.52%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Sulfalene AI Summary

Sulfalene exhibits bioactivity across a range of assays targeting diverse biological activities and infectious agents. It shows potent inhibitory effects in assays related to menin-MLL interaction in MLL-related leukemias, T. brucei phosphofructokinase, Eya2 phosphatase activity, and the delayed death pathway of the malarial parasite plastid. Furthermore, it can block the entry of Lassa and Ebola viruses. The compound also exhibits moderate antiviral activity against SARS-CoV-2, inhibiting induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM and inhibiting the SARS-CoV-2 3CL-Pro protease by 6.154% at 20 µM. In antibacterial assays, Sulfalene is effective against certain strains like sensitive Lactobacillus casei, Escherichia coli, and Streptococcus faecium, but is limited against chlorguanide triazine-resistant strains. It shows efficacy in antimalarial activity against Plasmodium berghei in mice with a median effective dose (MED) of 40.0 mg/kg and a minimum curative dose (MCD) of 160.0 mg/kg. Regarding its pharmacokinetics, Sulfalene has a plasma protein binding (PPB) of 76.81% and a distribution coefficient (LogD7.4) of -0.65, indicating moderate protein binding and low lipophilicity. Additionally, it exhibits 34.65% inhibition as an HDAC6 inhibitor in enzymatic assays using a commercial peptide substrate. Overall, Sulfalene demonstrates potential as a multi-target bioactive molecule with varying degrees of effectiveness across different biological pathways and infectious agents..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Sulfalene (SMP2), a long-acting sulfonamide antibiotic, is used for the therapy of chronic bronchitis, urinary tract infections, and malaria.
别名	磺胺林, Sulfametopyrazine, Sulfalene(SMPZ), Sulfalen, SMP2, Butadiene sulfone, AS-18908, 3-Sulfolene

化学信息

分子量	280.3
分子式	C₁₁H₁₂N₄O₃S
CAS No.	152-47-6
Smiles	COC1=C(NS(=O)(=O)C2=CC=C(N)C=C2)N=CC=N1
密度	1.465 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (160.54 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5676 mL	17.8380 mL	35.6761 mL	178.3803 mL
5 mM	0.7135 mL	3.5676 mL	7.1352 mL	35.6761 mL
10 mM	0.3568 mL	1.7838 mL	3.5676 mL	17.8380 mL
20 mM	0.1784 mL	0.8919 mL	1.7838 mL	8.9190 mL
50 mM	0.0714 mL	0.3568 mL	0.7135 mL	3.5676 mL
100 mM	0.0357 mL	0.1784 mL	0.3568 mL	1.7838 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。