Name: Rusfertide
Brand: TargetMol
SKU: TP2618
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

50 mg

待询

生物活性

产品描述	Rusfertide, a peptide mimetic of natural hepcidin, targets and degrades ferroportin, thereby reducing serum iron and transferrin saturation, which helps regulate red blood cell production. It ameliorates conditions such as polycythemia vera, β-thalassemia, and hereditary hemochromatosis [1] [2].
体内活性	Rusfertide 限制红细胞（RBCs）中的铁毒性（1 mg/kg，皮下注射，每两天一次，共49天）和转铁蛋白饱和度（2.5 mg/kg，皮下注射，每两天一次，共2周），提高红细胞的携氧能力，改善β-地中海贫血和遗传性血色素沉着症小鼠模型中的贫血和铁沉积，提高RBCs的生存率，减少转铁蛋白饱和度和铁沉积 [1]。 Animal Model: Hbb th3/+ mice model for β-thalassemia and hereditary hemochromatosis [1] Dosage: 1 and 2.5 mg/kg Administration: s.c., once every two days, for 49 days (1 mg/kg); or for 2 weeks (2.5 mg/kg) Result: Improved the survival rate of RBCs in β-thalassemia model. Reduced transferrin-saturation and iron deposition.
别名	PTG-300

化学信息

分子量	2441.95
分子式	C₁₁₄H₁₈₁N₂₇O₂₈S₂
CAS No.	1628323-80-7
Smiles	C([C@@H](NC([C@H](CC1=CN=CN1)NC([C@@H](NC([C@@H](NC(CC(C)C)=O)CC(O)=O)=O)[C@@H](C)O)=O)=O)CC2=CC=CC=C2)(=O)N3[C@H](C(N[C@@H]4C(=O)N[C@@]([C@H](CC)C)(C(=O)N[C@@H](CCCCNC(CC[C@H](NC(CCCCCCCCCCCCCCC)=O)C(O)=O)=O)C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N[C@@H](CCC(O)=O)C(=O)N6[C@](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@H](C(N[C@@H](CCCCN)C(N)=O)=O)CSSC4)(CCC6)[H])[H])=O)CCC3
Sequence	{Asp(N-(3-methyl-1-oxobutyl))}-Thr-His-Phe-Pro-Cys-Ile-{Lys(γGlu-C16 acid)}-Phe-Glu-Pro-Arg-Ser-Lys-Gly-Cys-Lys-NH2 (disulfide bridge: Cys6-Cys16)
Sequence Short	{Asp(N-(3-methyl-1-oxobutyl))}-THFPCI-{Lys(γGlu-C16 acid)}-FEPRSKGCK (disulfide bridge: Cys6-Cys16)

储存&溶解度

存储

Rusfertide