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RL648_81

Name: RL648_81
Brand: TargetMol
SKU: T28544
Price: 153 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.82%

货号 T28544Cas号 1919050-87-5

RL648_81 是 KCNQ2/3 通道的选择性激活剂 (EC50 = 190 nM)。 RL648_81 可用于神经元过度兴奋性神经系统疾病的研究。

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RL648_81

一键复制产品信息

很棒

纯度: 99.82%

货号 T28544Cas号 1919050-87-5

RL648_81 是 KCNQ2/3 通道的选择性激活剂 (EC50 = 190 nM)。 RL648_81 可用于神经元过度兴奋性神经系统疾病的研究。

规格	价格	库存
1 mg	¥ 153	现货
5 mg	¥ 358	现货
10 mg	¥ 596	现货
25 mg	¥ 1,180	现货
50 mg	¥ 1,930	现货
100 mg	¥ 2,850	现货
1 mL x 10 mM (in DMSO)	¥ 395	现货

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产品介绍

RL648_81 AI Summary

RL648_81 exhibits agonist activity on various Kv7 channels expressed in different cell lines, as demonstrated by whole-cell patch clamp electrophysiology assays. Specifically, it has an EC50 of 190.0 nM for human Kv7.2/7.3 channels in CHO cells and an EC2 ranging from 0.09 µM to 0.29 µM for different Kv7 channels in HEK293 cells. In particular, the compound has an EC2 of 0.1 µM for human Kv7.4 and an EC2 of 0.09 µM for human Kv7.4/7.5. Additionally, it exhibits selectivity with a selectivity index of 0.3 between Kv7.2/7.3 and Kv7.4/7.5 channels and a half-life of 5.733 hours in human liver microsomes. Moreover, in the SyncroPatch assay, at a 5 µM concentration, RL648_81 shifts the voltage-dependent activation of the Kv7.2 channel to more negative potentials, with a V1/2 value of -48.1 mV for Kv7.2 and 1.9 mV for the Kv7.2 W236L mutant. The compound demonstrates a dose-dependent response, increasing maximum current density and showing EC50 values ranging from 240.0 nM to 4000.0 nM, indicating a stimulatory effect on Kv7.2/7.3 channel activity..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	RL648_81 is a selective activator of KCNQ2/3 channels (EC50 = 190 nM). RL648_81 can be used in studies about neuronal hyperexcitability neurologic disorders.

化学信息

分子量	371.33
分子式	C₁₇H₁₇F₄N₃O₂
CAS No.	1919050-87-5
Smiles	CCOC(=O)Nc1ccc(NCc2ccc(cc2)C(F)(F)F)c(F)c1N
密度	1.398 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 27.5 mg/mL (74.06 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 2 mg/mL (5.39 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6930 mL	13.4651 mL	26.9302 mL	134.6511 mL
5 mM	0.5386 mL	2.6930 mL	5.3860 mL	26.9302 mL
10 mM	0.2693 mL	1.3465 mL	2.6930 mL	13.4651 mL
20 mM	0.1347 mL	0.6733 mL	1.3465 mL	6.7326 mL
50 mM	0.0539 mL	0.2693 mL	0.5386 mL	2.6930 mL