Name: PROTAC EZH2 Degrader-41
Brand: TargetMol
SKU: T218895
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

50 mg

待询

生物活性

产品描述	PROTAC EZH2 Degrader-41 is a PROTAC molecule targeting EZH2 and acts as a cIAPE3 E3 ubiquitin ligase recruiter. It promotes the degradation of EZH2 through ubiquitination and proteasomal pathways, exhibiting antiproliferative effects in lymphoma cells. This compound is applicable for research related to lymphoma.
体外活性	PROTAC EZH2 Degrader-41 (compound 57) 在 10.00-30.00 μM 范围内可于 SU-DHL-6 细胞中诱导 EZH2 降解；同时对 SU-DHL-6 和 HBL-1 弥漫性大 B 细胞淋巴瘤细胞增殖表现出显著抑制作用，IC 50 值分别为 10.22 μM 和 10.17 μM。

化学信息

分子量	1160.45
分子式	C₆₃H₈₉N₁₁O₁₀
CAS No.	3093642-41-9
Smiles	N(CC)(C1=CC(=CC(C(NCC2=C(C)C=C(C)NC2=O)=O)=C1C)C3=CC=C(CN4CCN(C(CCC5=CN(CCOCCOCCOCCNC([C@@H](NC([C@H]([C@@H](CC6=CC=CC=C6)N)O)=O)CC(C)C)=O)N=N5)=O)CC4)C=C3)C7CCOCC7

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

PROTAC EZH2 Degrader-41