Perfluoroundecanoic acid-13C7 is a 13C-labeled version of Perfluoroundecanoic acid, which is a perfluoroalkyl substance (PFAS). It is an orally effective inducer of oxidative stress, promoting macrophage M2 polarization by activating the Wnt/β-catenin signaling pathway and enhancing nuclear accumulation of β-catenin. M2 phenotype macrophages induced by Perfluoroundecanoic acid accelerate tumor progression both in vitro and in vivo. The compound induces DNA damage and reproductive as well as pathophysiological dysfunction in male Swiss mice through oxidative stress. It also inhibits Leydig cell development in pubertal male rats via oxidative stress and autophagy (Autophagy) induction. Additionally, Perfluoroundecanoic acid accelerates insulitis development in a type 1 diabetic mouse model and is useful for research in ovarian cancer, type 1 diabetes, and inflammation.

全氟十一烷酸-13C7, 二十一氟十一烷酸-13C7