Name: Mirvetuximab soravtansine
Brand: TargetMol
SKU: T77825
Price: 4740 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 4,740

现货

5 mg

¥ 13,300

现货

10 mg

¥ 17,800

现货

25 mg

¥ 26,600

现货

生物活性

产品描述	Mirvetuximab soravtansine (IMGN853) is an antibody-drug coupling (ADC) targeting folate receptor alpha (FRα), which inhibits cell growth and enhances the antiproliferative effects of DNA damage, and may be useful in the study of drug-resistant ovarian cancer.
体外活性	8 nM Mirvetuximab soravtansine 与 Carboplatin 联合使用处理 IGROV-1 cells，在体外显示增强的协同抑制生长和干扰细胞周期。[1]
体内活性	用SCID雌性小鼠患者来源的异种移植模型，静脉注射5 mg/kg Mirvetuximab soravtansin 能够提升Carboplatin在体内的抗肿瘤效果。[1]
别名	索米妥昔单抗, TAK-853, IMGN-853, IMGN853
反应种属	Human
验证活性	Immobilized Human FOLR1 Protein (His) (TMPY-01743) at 1 μg/mL (100 μL/well) can bind Mirvetuximab soravtansine. The EC50 is 3.66 ng/mL.
应用	ELISA FCM Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<10 EU/mg

抗体信息

同型

IgG1-DM4

偶联与修饰

偶联

DM4

抗原信息

化学信息

分子量	145.76 kDa
CAS No.	1453084-37-1

储存&溶解度

存储	-20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Mirvetuximab soravtansine