Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L-AP3 is a potent antagonist of metabotropic glutamate receptor (mGluR), demonstrating inhibitory effects on D-phosphoserine and L-phosphoserine with IC50 values of 368 μM and 2087 μM, respectively.
产品描述 | L-AP3 is a potent antagonist of metabotropic glutamate receptor (mGluR), demonstrating inhibitory effects on D-phosphoserine and L-phosphoserine with IC50 values of 368 μM and 2087 μM, respectively. |
体外活性 | L-AP3 inhibits D-phosphoserine and L-phosphoserine with K i s of 151 μM and 845 μM, respectively[1]. L-AP3 has agonistic activity in enhancing phospholipase D activity and decreasing CAMP formation in rat hippocampus[1]. L-AP3 may have selectivity for Group II subtypes since it inhibits [ 3 H]glutamate binding to mGlu3, receptors (K i 125 μM)[1]. L-AP3 is a potent inhibitor of sodium-dependent L-[ 3 H]glutamate uptake in cerebellar and cortical synaptosomes (39 and 110 μM, respectively)[1]. |
体内活性 | L-AP3 has anticonvulsant activity in animals. L-AP3 blocks audiogenic seizures in DBA/2 mice[1]. |
别名 | 3-Phosphono-L-alanine, L-AP3 |
分子量 | 169.073 |
分子式 | C3H8NO5P |
CAS No. | 23052-80-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
L-AP3 23052-80-4 LAP3 L-AP-3 3-Phosphono-L-alanine L AP3 Inhibitor inhibitor inhibit