规格

价格

库存

数量

10 mg

待询

10-14周

50 mg

待询

10-14周

生物活性

产品描述

Fluphenazine hydrochloride is an effective, orally active phenothiazine class dopamine receptor (dopamine receptor) antagonist. It blocks voltage-gated sodium ion channels (sodium channels) in neurons. The compound primarily exerts its effects by antagonizing postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular pathways. It counteracts stereotypy induced by methylphenidate in mice and suppresses climbing behavior. Fluphenazine hydrochloride is used in studying psychoses and diabetic-related painful peripheral neuropathy, with potential to inhibit SARS-CoV-2.

体内活性

Fluphenazine (1 mg/kg；IG，从妊娠第 6 天到第 15 天进行) hydrochloride 会引起孕鼠畸形 [5]。Fluphenazine (0.125-1 mg/kg；IP，单剂量) hydrochloride 抑制 Methylphenidate 诱导的刻板啃咬，并显著减少攀爬行为 [6]。