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Fluoroethylnormemantine hydrochloride

产品编号 T39119 CAS 1639210-25-5

Fluoroethylnormemantine hydrochloride, a Memantine derivative, functions as an antagonist for the N-methyl-D-aspartate (NMDA) receptor. It can also serve as a positron emission tomography (PET) tracer, specifically as [18F]-Fluoroethylnormemantine hydrochloride. Notably, this compound displays a range of effects, including anti-amnesic, neuroprotective, antidepressant-like, and fear-attenuating properties.

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Fluoroethylnormemantine hydrochloride Chemical Structure

Fluoroethylnormemantine hydrochloride, CAS 1639210-25-5

规格	价格/CNY		货期	数量
2 mg	￥ 2,990		5日内发货

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其他形式的 Fluoroethylnormemantine hydrochloride:

Fluoroethylnormemantine
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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述

体内活性

Fluoroethylnormemantine (0.1-10 mg/kg; a single i.p.) shows anti-amnesic effects on Aβ 25-35 -induced learning impairments in mice[1]. Fluoroethylnormemantine (0.1-10 mg/kg; i.p. once daily for 7 days) attenuates Aβ 25-35 -induced behavioral deficits, neuroinflammation, oxidative stress, apoptosis, and cell loss in mice[1]. Fluoroethylnormemantine (1-20 mg/kg; a single injection) decreases behavioral despair in the forced swim test (FST) and reduces fear behavior in the cued fear conditioning (FC) and extinction training in rats[2]. Animal Model: Male Swiss CD-1 mice (7-9 weeks) were injected with Aβ 25-35[1]Dosage: 0.1, 0.3, 1, 3, 10 mg/kg Administration: I.p. 30 minutes before the behavioral tests Result: Attenuated Aβ 25-35 -induced spontaneous alternation deficit, passive avoidance deficit, and novel object exploration deficit.

分子量	233.76
分子式	C12H21ClFN
CAS No.	1639210-25-5

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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参考文献

1. Couly S, et, al. Anti-Amnesic and Neuroprotective Effects of Fluoroethylnormemantine in a Pharmacological Mouse Model of Alzheimer's Disease. Int J Neuropsychopharmacol. 2021 Feb 15;24(2):142-157. 2. Chen BK, et, al. Fluoroethylnormemantine, a novel derivative of memantine, facilitates extinction learning without sensorimotor deficits. Int J Neuropsychopharmacol. 2021 Feb 25;pyab007. 3. Chen BK, et, al. Fluoroethylnormemantine, a novel NMDA receptor antagonist, for the prevention and treatment of stress-induced maladaptive behavior. Biological Psychiatry. 2021 May 9.

剂量换算

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体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

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