购物车
您的购物车当前为空
DDG-39
一键复制产品信息
很棒纯度: 99.17%
货号 T67797Cas号 119555-47-4
别名 1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine
DDG-39 (1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine)具有抗病毒活性，在细胞培养中具有有效的选择性抗 HIV-1 和HBV 活性。平均抗病毒 IC50为0.61μM。
为众多的药物研发团队赋能，
让新药发现更简单！
DDG-39
一键复制产品信息 很棒纯度: 99.17%
货号 T67797 别名 1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosineCas号 119555-47-4
DDG-39 (1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine)具有抗病毒活性，在细胞培养中具有有效的选择性抗 HIV-1 和HBV 活性。平均抗病毒 IC50为0.61μM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 1,320 | 现货 | |
| 5 mg | ¥ 3,260 | 现货 | |
| 10 mg | ¥ 4,760 | 现货 | |
| 25 mg | ¥ 7,490 | 现货 | |
| 50 mg | ¥ 9,870 | 现货 | |
| 100 mg | ¥ 13,300 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 2,920 | 现货 |
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
大包装 & 定制
加入购物车
该分子属于定制产品。TargetMol拥有优秀的合成团队，经验和能力，可以为您提供高性价比的产品。 如您有任何问题，欢迎咨询，我们将竭诚为您服务。
产品介绍
DDG-39 AI Summary
DDG-39 exhibits significant anti-HIV activity across multiple cell lines and assays. In MT-4 cells, it inhibits HIV-1 replication with an ED50 of 9.8 µM and displays cytotoxicity with a CD50 of 117.0 µM, resulting in a Selectivity Index (SI) of 12.0. Its antiviral efficacy extends to other assays, showing an IC50 of 700.0 nM in C8166 cells against the HIV-1 RF strain and low cytotoxicity indices across various cell lines, including PBM, CEM, Vero, and 2.2.15 cells, with IC50 values exceeding 100,000.0 nM. The compound demonstrates an EC50 of 16200.0 nM in human peripheral blood mononuclear cells for HIV-1 and exhibits anti-HBV activity with an EC50 of 4000.0 nM in 2.2.15 cells. Against HIV-1 in ATH8 cells, it protects against cytopathic effects ranging from 3.0% to 56.0% at various concentrations, with minimal cytotoxicity (0.0% to 8.0%). Moreover, it significantly inhibits HIV replication in various cell types such as CEM, U937, T-cell, MO, and PBL, with ID50 values between 0.14 µg/ml and 61.8 µg/ml, and a therapeutic index (TI) of 39.0 based on HIV-induced cytopathogenesis in CEM cells. Additionally, in MT-4 cells, it shows EC50 values of 2660.0 nM (P24 antigen ELISA) and 2540.0 nM (reverse transcriptase assay) with corresponding IC50 values of 872,000.0 nM and 707,000.0 nM in MT-4 and HL60 cells, respectively, yielding high selectivity ratios (266.0 to 343.0). The compound also inhibits radiolabeled amino acid incorporation by 50% at 500.0 µM, indicating robust antiviral potential with relatively low cytotoxicity..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | DDG-39 (1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine) possesses antiviral activity with potent and selective anti-HIV-1 and HBV activity in cell culture. The average antiviral IC50 is 0.61 μM. |
| 别名 | 1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine |
| 分子量 | 229.21 |
| 分子式 | C9H12FN3O3 |
| CAS No. | 119555-47-4 |
| Smiles | F[C@@H]1[C@@H](O[C@H](CO)C1)N2C(=O)N=C(N)C=C2 |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， 一共给药动物10只，您使用的配方为5%
DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
预览
Related Tags: buy DDG-39 | purchase DDG-39 | DDG-39 cost | order DDG-39 | DDG-39 chemical structure | DDG-39 formula | DDG-39 molecular weight
嗨！有任何问题？点我咨询
版权所有©2015-2026 TargetMol Chemicals Inc.保留所有权利.
沪ICP备20019793号-4 | 沪公网安备 31010602006700号
| 沪(静)应急管危经许[2024]203441