DDG-39

Name: DDG-39
Brand: TargetMol
SKU: T67797
Price: 1320 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine

货号 T67797Cas号 119555-47-4 一键复制产品信息纯度: 99.50%

很棒

DDG-39 (1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine)具有抗病毒活性，在细胞培养中具有有效的选择性抗 HIV-1 和HBV 活性。平均抗病毒 IC50为0.61μM。

DDG-39

一键复制产品信息

很棒

纯度: 99.50%

货号 T67797Cas号 119555-47-4

别名 1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine

DDG-39 (1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine)具有抗病毒活性，在细胞培养中具有有效的选择性抗 HIV-1 和HBV 活性。平均抗病毒 IC50为0.61μM。

规格	价格	库存
1 mg	¥ 1,320	现货
5 mg	¥ 3,260	现货
10 mg	¥ 4,760	现货
25 mg	¥ 7,490	现货
50 mg	¥ 9,870	现货
100 mg	¥ 13,300	现货
1 mL x 10 mM (in DMSO)	¥ 2,920	现货

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实验操作小课堂

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选择批次:

纯度: 99.50%

ee: 100%

颜色: 白色

性状: Solid

资源下载: COA CSFC FNMR HNMR ORP LCMS产品操作手册

产品介绍

DDG-39 AI Summary

DDG-39 exhibits significant anti-HIV activity across multiple cell lines and assays. In MT-4 cells, it inhibits HIV-1 replication with an ED50 of 9.8 µM and displays cytotoxicity with a CD50 of 117.0 µM, resulting in a Selectivity Index (SI) of 12.0. Its antiviral efficacy extends to other assays, showing an IC50 of 700.0 nM in C8166 cells against the HIV-1 RF strain and low cytotoxicity indices across various cell lines, including PBM, CEM, Vero, and 2.2.15 cells, with IC50 values exceeding 100,000.0 nM. The compound demonstrates an EC50 of 16200.0 nM in human peripheral blood mononuclear cells for HIV-1 and exhibits anti-HBV activity with an EC50 of 4000.0 nM in 2.2.15 cells. Against HIV-1 in ATH8 cells, it protects against cytopathic effects ranging from 3.0% to 56.0% at various concentrations, with minimal cytotoxicity (0.0% to 8.0%). Moreover, it significantly inhibits HIV replication in various cell types such as CEM, U937, T-cell, MO, and PBL, with ID50 values between 0.14 µg/ml and 61.8 µg/ml, and a therapeutic index (TI) of 39.0 based on HIV-induced cytopathogenesis in CEM cells. Additionally, in MT-4 cells, it shows EC50 values of 2660.0 nM (P24 antigen ELISA) and 2540.0 nM (reverse transcriptase assay) with corresponding IC50 values of 872,000.0 nM and 707,000.0 nM in MT-4 and HL60 cells, respectively, yielding high selectivity ratios (266.0 to 343.0). The compound also inhibits radiolabeled amino acid incorporation by 50% at 500.0 µM, indicating robust antiviral potential with relatively low cytotoxicity..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	DDG-39 (1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine) possesses antiviral activity with potent and selective anti-HIV-1 and HBV activity in cell culture. The average antiviral IC50 is 0.61 μM.
别名	1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine

化学信息

分子量	229.21
分子式	C₉H₁₂FN₃O₃
CAS No.	119555-47-4
Smiles	F[C@@H]1[C@@H](O[C@H](CO)C1)N2C(=O)N=C(N)C=C2

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year 实际储存温度请以COA为准

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。