cromolyn

Cromolyn is a chromone complex that acts as a mast cell stabilizer, preventing the release of histamine. Its mechanism of action is thought to involve an interference with the antigen-stimulated calcium transport across the mast cell membrane, thereby inhibiting mast cell release of histamine, leukotrienes, and other substances that cause hypersensitivity reactions.

5-Methyl cromolyn (C5OH) disodium 是一种Cromolyn类似物，也是S100P的抑制剂。它可以阻止S100P与其受体RAGE的结合，抑制NF-κB活性及细胞增殖，并促进Gemcitabine引发的细胞凋亡 (apoptosis)。5-Methyl cromolyn disodium 能减少同基因PDAC小鼠模型中的肿瘤生长和转移，且延长生存期。此化合物适用于胰腺癌研究，比如胰腺导管腺癌 (PDAC)。

Cromolyn sodium (FPL-670) 是一种GSK-3β抑制剂，IC50为 2.0 µM，有抗过敏作用。

Cromoglicic acid 可防止肥大细胞释放炎性化学物质，例如组胺。

Cromoglicic acid , cromolyn (USAN), cromoglycate (former BAN), or cromoglicate, is traditionally described as a mast cell stabilizer, and is commonly marketed as the sodium salt sodium cromoglicate or cromolyn sodium. This drug prevents the release of inflammatory chemicals such as histamine from mast cells. Because of their convenience (and perceived safety), leukotriene receptor antagonists have largely replaced it as the non-corticosteroid treatment of choice in the treatment of asthma. Cromoglicic acid requires administration four times daily, and does not provide additive benefit in combination with inhaled corticosteroids.

CID 2745687 是一种对人类 GPR35 具有中等效力、浓度依赖性的拮抗剂，其 pIC50 为 6.70。CID 2745687 无法在体外有效拮抗 Zaprinast 或 Cromolyn disodium 在啮齿动物 GPR35 同源物上的激动作用[1]。然而，CID 2745687 在小鼠体内能够逆转 Lodoxamide 介导的抗纤维化效果[2]。