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Clothianidin

Name: Clothianidin
Brand: TargetMol
SKU: T21153
Price: 117 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.87%

货号 T21153Cas号 210880-92-5

别名 噻虫胺, TI-435, TI435, TI 435, Celero

Clothianidin (TI 435) 是一种杀虫剂，作为乙酰胆碱的激动剂，可刺激 nAChR，从而激活突触后乙酰胆碱受体，但不抑制 AChE。

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Clothianidin

一键复制产品信息

很棒

纯度: 99.87%

货号 T21153 别名 噻虫胺, TI-435, TI435, TI 435, CeleroCas号 210880-92-5

Clothianidin (TI 435) 是一种杀虫剂，作为乙酰胆碱的激动剂，可刺激 nAChR，从而激活突触后乙酰胆碱受体，但不抑制 AChE。

规格	价格	库存
10 mg	¥ 117	现货
25 mg	¥ 178	现货
50 mg	¥ 251	现货
100 mg	¥ 394	现货
200 mg	¥ 593	现货
500 mg	¥ 980	现货
1 g	¥ 1,490	现货
1 mL x 10 mM (in DMSO)	¥ 117	现货

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纯度: 99.87%

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COA LCMS HNMR 产品操作手册

产品介绍

Clothianidin AI Summary

Clothianidin displays diverse bioactivities and possesses significant potential as an acetylcholinesterase inhibitor and insecticide. In assays involving Aplysia AChBP expressed in HEK293S cells, it shows Ki values of 808 nM for [3H]ACE displacement and 574 nM for [3H]EPI displacement. Furthermore, Clothianidin acts as an agonist of glucocorticoid receptor signaling (89.1 nM potency), activates the p53 (28183.8 nM potency) and ARE signaling pathways (61130.6 nM potency), and inhibits Oryctolagus cuniculus AOX and Agaricus bisporus tyrosinase at IC50 concentrations, displaying some inhibition against xanthine oxidase with an IC50 of 1860000 nM. The compound exhibits high insecticidal efficacy, demonstrating 100% mortality in adult Aphis gossypii on cucumber cotyledons at 500 ppm after 72 hours and significant binding to [3H]IMI from nicotinic acetylcholine receptors in Drosophila melanogaster brain with a Ki of 4.0 nM. It also displaces [3H]IMI from nicotinic acetylcholine receptors in numerous insect species (IC50 values 1.8 nM to 9.2 nM), suggesting its use as a potent insecticide. It effectively inhibits first-instar larvae of Cheumatopsyche brevilineata (EC50 0.00444 µg/mL) and demonstrates insecticidal activity against Daphnia magna (EC50 >119 µg/mL). Clothianidin also shows strong insecticidal activity against both neonicotinoid-resistant and susceptible strains of Myzus persicae, with a high resistance index of 3013.0 and low LC50 of 0.3 ppm in susceptible strains. Additionally, it significantly reduces the body weight, honeydew excretion, and survival of imidacloprid-resistant Aphis gossypii. In beetle species, it achieves near-total mortality in Anomala orientalis (98.6%) and Maladera castanea (100%) after 30 days. Moreover, it effectively binds to the nAChR receptors in aphids, showing Ki values of 0.058 nM for [3H]-methyl-SFX displacement. Against Paralobesia viteana and Popillia japonica, the compound effectively reduces infestation and leaf damage using irrigation injection methods. In agricultural settings, it inhibits larval development of Contarinia nasturtii and emergence of Ceutorhynchus obstrictus adults in treated plants. Lastly, in Urochloa mutica (buffalo grass), it shows progressive drug uptake, reaching 6.48 µg/g of fresh weight after 3 days. Overall, Clothianidin's interdisciplinary activities, including its potential as an acetylcholinesterase inhibitor and versatile insecticidal properties, highlight it as a strong candidate for various applications in pest control and biochemical research..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Clothianidin (TI 435), an insecticide, acts as an agonist of acetylcholine to stimulate nAChR, thereby activating post-synaptic acetylcholine receptors but not inhibiting AChE.
别名	噻虫胺, TI-435, TI435, TI 435, Celero

化学信息

分子量	249.68
分子式	C₆H₈ClN₅O₂S
CAS No.	210880-92-5
Smiles	C\N=C(\NCc1cnc(Cl)s1)N[N+]([O-])=O
密度	1.61

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 125 mg/mL (500.64 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.01 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0051 mL	20.0256 mL	40.0513 mL	200.2563 mL
5 mM	0.8010 mL	4.0051 mL	8.0103 mL	40.0513 mL
10 mM	0.4005 mL	2.0026 mL	4.0051 mL	20.0256 mL
20 mM	0.2003 mL	1.0013 mL	2.0026 mL	10.0128 mL
50 mM	0.0801 mL	0.4005 mL	0.8010 mL	4.0051 mL
100 mM	0.0401 mL	0.2003 mL	0.4005 mL	2.0026 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。