Name: Canakinumab
Brand: TargetMol
SKU: T73695
Price: 3290 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 3,290

现货

5 mg

¥ 7,260

现货

10 mg

¥ 9,790

现货

25 mg

¥ 14,500

现货

50 mg

¥ 19,600

现货

生物活性

产品描述	Canakinumab (ACZ885) is a recombinant human IL-1β-targeting monoclonal antibody.Canakinumab has been shown to inhibit human and chorioallantoic monkey IL-1β, with IC50 values of 43.6 and 40.8 pM, respectively.Canakinumab has anti-inflammatory activity, inhibiting inflammation associated with autoimmune diseases by neutralizing IL-1β signaling. Canakinumab has anti-inflammatory activity, inhibiting inflammation associated with autoimmune diseases by neutralizing IL-1β signaling.Canakinumab has been used for the treatment of gout and coronary artery disease.
靶点活性	IL-1β:43.6 pM (human), IL-1β:40.8 pM (marmoset)
体外活性	Canakinumab（0-7 nM）在剂量依赖性的条件下，抑制了狨猴外周血单个核细胞中的IL-6产生，对人类和狨猴的IL-1β分别展现出43.6和40.8 pM的IC50值[2]。有效地，Canakinumab与IL-1RI和IL-1RII竞争结合到IL-1b上[2]。
别名	卡纳奴单抗, 卡那奴单抗, Ilaris, ACZ 885
反应种属	Human
应用	ELISA FCM Functional assay
抗体种类	Monoclonal
内毒素	< 1 EU/mg as determined by the LAL method

抗体信息

同型	Human IgG1 kappa
推荐同型对照	Human IgG1 kappa, Isotype Control

偶联与修饰

偶联	Unconjugated

抗原信息

化学信息

储存&溶解度

存储	store at low temperature \| -20°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

Canakinumab